Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | GRK2 | P25098 | 1/20 | 0.39 |
| ▸ | GRK5 | P34947 | 1/20 | 0.39 |
| ▸ | GRK3 | P35626 | 1/20 | 0.39 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.38 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.38 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
| ▸ | KCNK3 | O14649 | 2/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8750849 | 1.00 | MAPT (0.44) | MAPTSMN1; SMN2LMNAALDH1A1NPSR1 | |
| SCHEMBL8750752 | 0.86 | FAAH (0.42) | SMN1; SMN2ALDH1A1SCN2ASCN10ANPC1 | |
| SCHEMBL8750758 | 0.86 | FAAH (0.42) | SMN1; SMN2ALDH1A1SCN2ASCN10ANPC1 | |
| SCHEMBL8750733 | 0.84 | HRH4 (0.37) | ALDH1A1SCN2ASCN10ANAMPTKDR | |
| SCHEMBL8750735 | 0.84 | HRH4 (0.37) | ALDH1A1SCN2ASCN10ANAMPTKDR | |
| SCHEMBL8750815 | 0.83 | HTR3E (0.38) | SMN1; SMN2ALDH1A1NTRK1SCN2ASCN10A | |
| SCHEMBL8750820 | 0.83 | HTR3E (0.38) | SMN1; SMN2ALDH1A1NTRK1SCN2ASCN10A | |
| SCHEMBL8750851 | 0.83 | GRK2 (0.36) | ALDH1A1KDM4EGRK2NTRK1SCN2A | |
| SCHEMBL8750847 | 0.83 | GRK2 (0.36) | ALDH1A1KDM4EGRK2NTRK1SCN2A | |
| SCHEMBL8750772 | 0.83 | HTR3E (0.38) | ALDH1A1NTRK1SCN2ASCN10AKCNJ11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0634400-B1 | PYRIDINECARBOXIMIDAMIDE COMPOUND AND USE THEREOF | KIRIN BREWERY (JP) | 1997-04-02 | — | — | EP | disclosed |
| US-5508293-A | TREATING HYPERTENSION, ANGINA PECTORIS | KIRIN BEER KABUSHIKI KAISHA (JP) | 1996-04-16 | — | — | US | disclosed |
| EP-0634400-A1 | PYRIDINECARBOXIMIDAMIDE COMPOUND AND USE THEREOF | KIRIN BEER KABUSHIKI KAISHA (JP) | 1995-01-18 | — | — | EP | disclosed |