Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.47 |
| ▸ | P2RX7 | Q99572 | 4/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.41 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.39 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8750766 | 0.89 | P2RX7 (0.42) | MAPTHIF1AP2RX7CNR1SCN2A | |
| SCHEMBL8750762 | 0.86 | HIF1A (0.46) | HIF1AP2RX7CNR1SCN2ASCN10A | |
| SCHEMBL8750736 | 0.83 | HIF1A (0.38) | LMNAHIF1AP2RX7CNR1SCN2A | |
| SCHEMBL8750822 | 0.83 | P2RX7 (0.37) | MAPTHIF1AP2RX7CNR1SCN2A | |
| SCHEMBL8750765 | 0.83 | KDM4E (0.39) | MAPTHIF1AP2RX7CNR1SCN2A | |
| SCHEMBL8750775 | 0.82 | HIF1A (0.38) | MAPTHIF1AP2RX7CNR1SCN2A | |
| SCHEMBL8750856 | 0.82 | MAPT (0.44) | LMNAMAPTSMN1; SMN2HIF1ASCN2A | |
| SCHEMBL8750849 | 0.82 | MAPT (0.44) | LMNAMAPTSMN1; SMN2HIF1ASCN2A | |
| SCHEMBL8750824 | 0.81 | HIF1A (0.40) | HIF1AP2RX7CNR1SCN2ASCN10A | |
| SCHEMBL8750770 | 0.81 | KDR (0.36) | HIF1AP2RX7CNR1SCN2ASCN10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0634400-B1 | PYRIDINECARBOXIMIDAMIDE COMPOUND AND USE THEREOF | KIRIN BREWERY (JP) | 1997-04-02 | — | — | EP | disclosed |
| US-5508293-A | TREATING HYPERTENSION, ANGINA PECTORIS | KIRIN BEER KABUSHIKI KAISHA (JP) | 1996-04-16 | — | — | US | disclosed |
| EP-0634400-A1 | PYRIDINECARBOXIMIDAMIDE COMPOUND AND USE THEREOF | KIRIN BEER KABUSHIKI KAISHA (JP) | 1995-01-18 | — | — | EP | disclosed |