Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 6/20 | 0.47 |
| ▸ | KIT | P10721 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
| ▸ | TYK2 | P29597 | 1/20 | 0.41 |
| ▸ | JAK3 | P52333 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.40 |
| ▸ | PRMT3 | O60678 | 1/20 | 0.40 |
| ▸ | ATR | Q13535 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL875170 | 0.92 | HDAC1 (0.41) | NAMPTKITHDAC1JAK2JAK1 | |
| SCHEMBL874755 | 0.87 | NAMPT (0.47) | NAMPTKITHDAC1CHRM1HTR2A | |
| SCHEMBL874891 | 0.85 | HDAC1 (0.50) | NAMPTHDAC1POLB | |
| SCHEMBL874266 | 0.83 | NAMPT (0.49) | NAMPTKITHDAC1CHRM1HTR2A | |
| SCHEMBL874795 | 0.81 | NAMPT (0.47) | NAMPTKITHDAC1CHRM1HTR2A | |
| SCHEMBL3054387 | 0.81 | NAMPT (0.47) | NAMPTKITHDAC1CHRM1HTR2A | |
| SCHEMBL3050002 | 0.81 | NAMPT (0.47) | NAMPTKITHDAC1CHRM1HTR2A | |
| SCHEMBL874813 | 0.80 | NAMPT (0.48) | NAMPTKITHDAC1MCHR1ATR | |
| SCHEMBL3046413 | 0.80 | NAMPT (0.46) | NAMPTKITHDAC1CHRM1HTR2A | |
| SCHEMBL882909 | 0.79 | NAMPT (0.49) | NAMPTKITHDAC1JAK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012038904-A1 | NICOTINAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2012-03-29 | — | — | WO | disclosed |