SCHEMBL8758563

SCHEMBL8758563

C=Cc1cccc(-c2ccc3c(ccc4ccccc43)c2)c1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.44
HSD17B10 Q99714 3/20 0.44
CYP1B1 Q16678 2/20 0.44
HIF1A Q16665 1/20 0.44
PTGS2 P35354 1/20 0.42
HPRT1 P00492 3/20 0.42
CYP1A2 P05177 5/20 0.41
ERBB2 P04626 1/20 0.41
FYN P06241 1/20 0.41
MAOA P21397 1/20 0.41
ACHE P22303 1/20 0.41
AHR P35869 1/20 0.41
TDP1 Q9NUW8 2/20 0.40
TSHR P16473 2/20 0.40
ESR1 P03372 2/20 0.40
ESR2 Q92731 2/20 0.40
CYP2A6 P11509 1/20 0.40
HSD17B1 P14061 5/20 0.40
HSD17B2 P37059 5/20 0.40
TP53 P04637 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8758709 0.92 ALDH1A1 (0.45) ALDH1A1HSD17B10CYP1B1HIF1APTGS2
SCHEMBL5888641 0.86 ALDH1A1 (0.47) ALDH1A1HSD17B10CYP1B1HIF1AHPRT1
SCHEMBL7035082 0.86 HSD17B1 (0.53) ALDH1A1HSD17B10CYP1B1PTGS2CYP1A2
SCHEMBL8758873 0.85 HPRT1 (0.45) ALDH1A1HSD17B10CYP1B1HIF1APTGS2
SCHEMBL9570894 0.84 CA12 (0.43) ALDH1A1PTGS2CYP1A2ESR1ESR2
SCHEMBL8758720 0.84 HSD17B1 (0.47) ALDH1A1HSD17B10CYP1B1HIF1APTGS2
SCHEMBL449311 0.82 ALDH1A1 (0.54) ALDH1A1HSD17B10CYP1B1HIF1AHPRT1
SCHEMBL8758702 0.81 CYP11B1 (0.47) ALDH1A1HSD17B10CYP1B1HIF1APTGS2
SCHEMBL27686717 0.80 HPRT1 (0.56) ALDH1A1HSD17B10CYP1B1HIF1AHPRT1
SCHEMBL25412097 0.80 ALDH1A1 (0.67) ALDH1A1HSD17B10CYP1B1HIF1AHPRT1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0570932-B1 Styrenic block copolymer and process for producing same IDEMITSU KOSAN CO (JP) 1997-07-23 EP disclosed
EP-0559108-B1 Graft copolymer, process for production thereof and resin composition containing same IDEMITSU KOSAN CO (JP) 1997-05-28 EP disclosed
US-5554695-A Styrenic copolymer and process for producing same IDEMITSU KOSAN CO. LTD. (JP) 1996-09-10 US disclosed
EP-0511407-B1 STYRENIC COPOLYMER AND PRODUCTION THEREOF IDEMITSU KOSAN CO (JP) 1996-05-29 EP disclosed
EP-0490269-B1 Graft copolymer and process for producing the same IDEMITSU KOSAN CO (JP) 1996-02-28 EP disclosed
US-5475061-A High degree of syndiotactic configuration; using alumoxane and transition metal compound catalysts IDEMITSU KOSAN CO., LTD. (JP) 1995-12-12 US disclosed
EP-0444210-B1 ARYLSTYRENE POLYMER AND COPOLYMER AND PROCESS FOR PREPARING THE SAME IDEMITSU KOSAN CO (JP) 1995-05-24 EP disclosed
US-5418276-A Styrene copolymer, syndiotactic, heat resistance, chemical resistance IDEMITSU KOSAN CO., LTD. (JP) 1995-05-23 US disclosed
US-5418290-A Compatability with other resins, adhesion IDEMITSU KOSAN CO., LTD. (JP) 1995-05-23 US disclosed
US-5403908-A Aryl styrene-based copolymer IDEMITSU KOSAN COMPANY, LIMITED (JP) 1995-04-04 US disclosed
US-5391626-A Syndiotactic, high performance, compatibility and adhesiveness; molding materials IDEMITSU KOSAN CO., LTD. (JP) 1995-02-21 US disclosed
US-5362814-A Styrene polymers with olefin monomers and diolefin monomers for impact strength in molding materials IDEMITSU KOSAN CO., LTD. (JP) 1994-11-08 US disclosed
EP-0570931-A2 Styrenic polymer, process for producing same and multi-layer material comprising same IDEMITSU KOSAN COMPANY LIMITED (JP) 1993-11-24 EP disclosed
EP-0570932-A2 Styrenic block copolymer and process for producing same IDEMITSU KOSAN COMPANY LIMITED (JP) 1993-11-24 EP disclosed
US-5250629-A Graft polymerization of styrene and ethylenically unsaturated monomer using transition metal catalysts, organoaluminum compounds; films, packaging, automobile parts IDEMITSU KOSAN CO., LTD. (JP) 1993-10-05 US disclosed
EP-0559108-A1 Graft copolymer, process for production thereof and resin composition containing same IDEMITSU KOSAN COMPANY LIMITED (JP) 1993-09-08 EP disclosed
EP-0511407-A1 STYRENIC COPOLYMER AND PRODUCTION THEREOF IDEMITSU KOSAN COMPANY LIMITED (JP) 1992-11-04 EP disclosed
EP-0490269-A1 Graft copolymer and process for producing the same IDEMITSU KOSAN COMPANY LIMITED (JP) 1992-06-17 EP disclosed
EP-0444210-A1 ARYLSTYRENE POLYMER AND COPOLYMER AND PROCESS FOR PREPARING THE SAME IDEMITSU KOSAN COMPANY LIMITED (JP) 1991-09-04 EP disclosed