SCHEMBL8759366

SCHEMBL8759366

COC(=O)C(=NO)c1ccccc1Oc1ccc(C)cc1

nearest known ligand 0.47

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 0.47
MEN1 O00255 3/20 0.45
KMT2A Q03164 3/20 0.45
GAA P10253 2/20 0.43
HTT P42858 1/20 0.43
RAB9A P51151 2/20 0.43
PNLIP P16233 1/20 0.43
CYP1A2 P05177 1/20 0.43
CYP3A4 P08684 1/20 0.43
CYP2C9 P11712 1/20 0.43
CYP2C19 P33261 1/20 0.43
CTNNB1 P35222 1/20 0.42
HTR2A P28223 1/20 0.40
SLC6A4 P31645 1/20 0.40
CASP1 P29466 1/20 0.39
KCNMA1 Q12791 1/20 0.39
NPSR1 Q6W5P4 1/20 0.39
L3MBTL1 Q9Y468 1/20 0.39
TSHR P16473 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8759357 1.00 LMNA (0.47) LMNAMEN1KMT2AGAAHTT
SCHEMBL8759289 0.90 CTNNB1 (0.53) LMNAMEN1KMT2AGAAHTT
SCHEMBL8301449 0.90 CTNNB1 (0.53) LMNAMEN1KMT2AGAAHTT
SCHEMBL8924997 0.88 HIF1A (0.46) LMNAMEN1KMT2AGAAHTT
SCHEMBL8925009 0.88 HIF1A (0.46) LMNAMEN1KMT2AGAAHTT
SCHEMBL8923108 0.86 LMNA (0.49) LMNAMEN1KMT2AGAAHTT
SCHEMBL8923119 0.86 LMNA (0.49) LMNAMEN1KMT2AGAAHTT
SCHEMBL2154272 0.85 LMNA (0.46) LMNAMEN1KMT2AGAAHTT
SCHEMBL2154270 0.85 LMNA (0.46) LMNAMEN1KMT2AGAAHTT
SCHEMBL432 0.79 MEN1 (0.56) LMNAMEN1KMT2AGAAHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5650539-A ALKYLATION, ESTERIFICATION, DEESTERIFICATION, AMIDATION, FUNGICIDES SHIONOGI & CO., LTD. (JP) 1997-07-22 US disclosed
EP-0605392-B1 Process for producing methoxyminoacetamide compounds SHIONOGI & CO (JP) 1997-04-09 EP disclosed
US-5488159-A AMIDATION, METHYLATION, FUNGICIDE SHIONOGI & CO., LTD. (JP) 1996-01-30 US disclosed
US-5380913-A E-Isomers of 2-methoxyimino-N-methyl-2-phenoxyphenylacetamides and alkyl 2-methoxyimino-2-phenoxyphenylacetates produced by reacting Z-isomers with hydrogen chloride or hydrochloric, sulfuric or toluenesulfonic acid in methyl, ethyl or butyl alc SHIONOGI & CO., LTD. (JP) 1995-01-10 US disclosed
EP-0468775-B1 Process for producing methoxyiminoacetamide compounds and intermediates SHIONOGI & CO (JP) 1994-12-14 EP disclosed
EP-0606924-A1 Process for producing E-isomers of methoxyminoacetamide compounds SHIONOGI SEIYAKU KABUSHIKI KAISHA trading under the name of SHIONOGI & CO. LTD. (JP) 1994-07-20 EP disclosed
EP-0605392-A1 Process for producing methoxyminoacetamide compounds SHIONOGI SEIYAKU KABUSHIKI KAISHA trading under the name of SHIONOGI & CO. LTD. (JP) 1994-07-06 EP disclosed
US-5183921-A Agricultural fungicides SHIONOGI & CO., LTD. (JP) 1993-02-02 US disclosed
EP-0468775-A1 Process for producing methoxyiminoacetamide compounds and intermediates SHIONOGI SEIYAKU KABUSHIKI KAISHA trading under the name of SHIONOGI & CO. LTD. (JP) 1992-01-29 EP disclosed