Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT6 | Q8N6T7 | 2/20 | 0.56 |
| ▸ | POLB | P06746 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 5/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27583942 | 0.82 | SIRT6 (0.60) | SIRT6POLBMAPTALDH1A1ADRB1 | |
| SCHEMBL6151230 | 0.80 | SIRT6 (0.81) | SIRT6POLBMAPTALDH1A1ADRB1 | |
| SCHEMBL15271381 | 0.80 | SIRT6 (0.81) | SIRT6POLBMAPTALDH1A1ADRB1 | |
| SCHEMBL4013778 | 0.80 | HTR3E (0.46) | POLBMAPTALDH1A1ADRB1LMNA | |
| SCHEMBL374834 | 0.78 | SIRT6 (0.68) | SIRT6POLBMAPTALDH1A1ADRB1 | |
| SCHEMBL4014691 | 0.78 | MAPT (0.49) | POLBMAPTALDH1A1LMNAGAA | |
| SCHEMBL4507720 | 0.76 | SIRT6 (0.65) | SIRT6POLBMAPTALDH1A1ADRB1 | |
| SCHEMBL1646512 | 0.76 | SIRT6 (0.65) | SIRT6POLBMAPTALDH1A1ADRB1 | |
| SCHEMBL27591247 | 0.76 | SIRT6 (0.52) | SIRT6POLBMAPTALDH1A1ADRB1 | |
| SCHEMBL1989595 | 0.76 | SIRT6 (0.64) | SIRT6POLBMAPTALDH1A1ADRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0773937-A1 | NOVEL ARYL PIPERAZINE-DERIVED PIPERAZIDE DERIVATIVES, METHODS FOR THEIR PREPARATION, THEIR USE AS DRUGS AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAME | PIERRE FABRE MEDICAMENT (FR) | 1997-05-21 | — | — | EP | disclosed |
| WO-1996002525-A1 | NOVEL ARYL PIPERAZINE-DERIVED PIPERAZIDE DERIVATIVES, METHODS FOR THEIR PREPARATION, THEIR USE AS DRUGS AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAME | PIERRE FABRE MEDICAMENT (FR) | 1996-02-01 | — | — | WO | disclosed |