Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 3/20 | 0.45 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.43 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.43 |
| ▸ | IDO1 | P14902 | 2/20 | 0.42 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.42 |
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
| ▸ | PPARA | Q07869 | 1/20 | 0.42 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA7 | P43166 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 2/20 | 0.39 |
| ▸ | RAF1 | P04049 | 2/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | BRAF | P15056 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5668761 | 0.81 | PPARG (0.52) | ARCHEK2IDO1GPR84PPARG | |
| SCHEMBL6511184 | 0.79 | MAOA (0.50) | ARSCN9ACHEK2IDO1PLA2G7 | |
| SCHEMBL18235652 | 0.79 | AR (0.49) | ARSCN9ACHEK2IDO1PPARG | |
| SCHEMBL876272 | 0.79 | AR (0.49) | ARCHEK2IDO1PPARGPPARA | |
| SCHEMBL14656234 | 0.79 | AR (0.49) | ARSCN9ACHEK2IDO1PPARG | |
| SCHEMBL875870 | 0.78 | AR (0.48) | ARSCN9ACHEK2IDO1PPARG | |
| SCHEMBL2396132 | 0.78 | AR (0.51) | ARSCN9ACHEK2IDO1PPARG | |
| SCHEMBL24998721 | 0.77 | PPARG (0.51) | ARSCN9ACHEK2IDO1PPARG | |
| SCHEMBL875873 | 0.77 | AR (0.47) | ARSCN9ACHEK2IDO1PPARG | |
| SCHEMBL13945703 | 0.77 | AR (0.47) | ARSCN9ACHEK2IDO1CA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2619203-A1 | TRICYCLIC COMPOUNDS, PREPARATION METHODS, AND THEIR USES | Glaxo Group Limited (GB) | 2013-07-31 | — | — | EP | disclosed |
| WO-2012037782-A1 | TRICYCLIC COMPOUNDS, PREPARATION METHODS, AND THEIR USES | GLAXO GROUP LIMITED (GB) | 2012-03-29 | — | — | WO | disclosed |