SCHEMBL8763164

SCHEMBL8763164

CCc1cccc(Cc2cccc(CC)c2C#N)c1C#N

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GABRA1 P14867 4/20 0.48
GABRB2 P47870 4/20 0.48
ALDH1A1 P00352 5/20 0.36
KDM4E B2RXH2 3/20 0.36
LMNA P02545 1/20 0.36
GAA P10253 3/20 0.36
MAPT P10636 3/20 0.36
GRIA2 P42262 3/20 0.36
GRIA4 P48058 3/20 0.36
GLA P06280 1/20 0.36
HPGD P15428 1/20 0.36
HTT P42858 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
TDP1 Q9NUW8 1/20 0.36
CYP2A6 P11509 1/20 0.35
MGLL Q99685 1/20 0.35
KMT2A Q03164 2/20 0.35
MEN1 O00255 1/20 0.35
S1PR1 P21453 1/20 0.35
KCNH2 Q12809 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9712661 0.93 GABRA1 (0.48) GABRA1GABRB2ALDH1A1KDM4ELMNA
Ethane SCHEMBL2154466 0.91 GABRA1 (0.46) GABRA1GABRB2ALDH1A1KDM4ELMNA
SCHEMBL16959698 0.83 S1PR1 (0.48) GABRA1GABRB2ALDH1A1KDM4ELMNA
SCHEMBL5083742 0.82 ALDH1A1 (0.41) GABRA1GABRB2ALDH1A1KDM4ELMNA
SCHEMBL2154140 0.82 KDM4E (0.40) GABRA1GABRB2ALDH1A1KDM4ELMNA
SCHEMBL11524213 0.81 GABRA1 (0.41) GABRA1GABRB2GRIA2GRIA4SMN1; SMN2
SCHEMBL3859990 0.81 CYP1A2 (0.47) GABRA1GABRB2ALDH1A1KDM4ELMNA
SCHEMBL8400778 0.80 BID (0.38) GABRA1GABRB2ALDH1A1KDM4ELMNA
SCHEMBL15680092 0.80 KDM4E (0.45) GABRA1GABRB2ALDH1A1KDM4EGAA
SCHEMBL14115760 0.79 GABRA1 (0.50) GABRA1GABRB2ALDH1A1KDM4ELMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0349195-B1 Direct synthesis by cationic polymerization of nitrogen-containing polymers EXXON CHEMICAL PATENTS INC (US) 1997-05-21 EP disclosed
US-5444135-A Polymerization and functionalization with nitrogen-containing functional groups occur simultaneously EXXON CHEMICAL PATENTS INC. (US) 1995-08-22 US disclosed
US-5336745-A Terminally-substituted polymeric compositions from cationically polymerizable monomers and initiators EXXON CHEMICAL PATENTS INC. (US) 1994-08-09 US disclosed