Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 5/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8659272 | 0.87 | — | — | |
| SCHEMBL29602999 | 0.74 | LMNA (0.52) | — | |
| SCHEMBL62071 | 0.74 | LMNA (0.52) | — | |
| SCHEMBL6402381 | 0.72 | EGFR (0.33) | EGFR | |
| SCHEMBL25850566 | 0.72 | EGFR (0.48) | EGFR | |
| SCHEMBL2868443 | 0.67 | IMPDH2 (0.40) | — | |
| SCHEMBL4706874 | 0.66 | CYP11B1 (0.37) | EGFR | |
| SCHEMBL28633281 | 0.63 | HIPK2 (0.40) | — | |
| SCHEMBL1200494 | 0.63 | PARP1 (0.37) | — | |
| SCHEMBL13859941 | 0.63 | EGFR (0.46) | EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 75 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0133234-B1 | IMIDAZOQUINAZOLIN-2-ONE COMPOUNDS PROCESS FOR THEIR PRODUCTION AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAID COMPOUNDS | DAIICHI SEIYAKU CO., LTD. (JP) | 1989-04-12 | — | — | EP | claimed |
| US-4610987-A | ANTICOAGULANT | DAIICHI SEIYAKU CO., LTD. (JP) | 1986-09-09 | — | — | US | claimed |
| EP-0133234-A2 | Imidazoquinazolin-2-one compounds process for their production and pharmaceutical compositions containing said compounds | DAIICHI SEIYAKU CO., LTD. (JP) | 1985-02-20 | — | — | EP | claimed |
| EP-3806888-B1 | PDE5 DERIVED REGULATORY CONSTRUCTS AND METHODS OF USE IN IMMUNOTHERAPY | OBSIDIAN THERAPEUTICS INC (US) | 2024-01-31 | — | — | EP | disclosed |
| US-11666642-B2 | PDE5 compositions and methods for immunotherapy | OBSIDIAN THERAPEUTICS, INC. (US) | 2023-06-06 | — | — | US | disclosed |
| CN-115197225-B | Five-membered heterocyclic quinazolinone compound and preparation method thereof | 贵州大学 | 2023-04-11 | — | — | CN | disclosed |
| US-20230074330-A1 | PDE5 COMPOSITIONS AND METHODS FOR IMMUNOTHERAPY | OBSIDIAN THERAPEUTICS, INC. (US) | 2023-03-09 | — | — | US | disclosed |
| US-20220403001-A1 | PDE5 DERIVED REGULATORY CONSTRUCTS AND METHODS OF USE IN IMMUNOTHERAPY | OBSIDIAN THERAPEUTICS, INC. (US) | 2022-12-22 | — | — | US | disclosed |
| CN-115197225-A | Five-membered heterocyclic quinazolinone compound and preparation method thereof | 贵州大学 | 2022-10-18 | — | — | CN | disclosed |
| US-11324746-B2 | Use of anagrelide for treating cancer | AROVELLA THERAPEUTICS LIMITED (AU) | 2022-05-10 | — | — | US | disclosed |
| US-11241485-B2 | PDE5 compositions and methods for immunotherapy | OBSIDIAN THERAPEUTICS, INC. (US) | 2022-02-08 | — | — | US | disclosed |
| WO-1995000512-A1 | POSITIVE INOTROPIC AND LUSITROPIC PYRROLOQUINOLINONE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1995-01-05 | — | — | WO | disclosed |
| EP-0514917-A1 | Process for and 2-(cyanoimino)-quinazoline derivatives useful as intermediates in the preparation of 6,7-di-(chloro)-1,5-di(hydro)-imidazo-[2,1-b]quinazolin-2[3H]-one and process for preparing the 2-(cyanoimino)-quinazoline derivatives | EGIS GYOGYSZERGYAR (HU) | 1992-11-25 | — | — | EP | disclosed |
| EP-0133234-B1 | IMIDAZOQUINAZOLIN-2-ONE COMPOUNDS PROCESS FOR THEIR PRODUCTION AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAID COMPOUNDS | DAIICHI SEIYAKU CO., LTD. (JP) | 1989-04-12 | — | — | EP | disclosed |
| US-4610987-A | ANTICOAGULANT | DAIICHI SEIYAKU CO., LTD. (JP) | 1986-09-09 | — | — | US | disclosed |
| US-4610987-A | ANTICOAGULANT | DAIICHI SEIYAKU CO., LTD. (JP) | 1986-09-09 | — | — | US | disclosed |
| US-4610987-A | ANTICOAGULANT | DAIICHI SEIYAKU CO., LTD. (JP) | 1986-09-09 | — | — | US | disclosed |
| EP-0133234-A2 | Imidazoquinazolin-2-one compounds process for their production and pharmaceutical compositions containing said compounds | DAIICHI SEIYAKU CO., LTD. (JP) | 1985-02-20 | — | — | EP | disclosed |
| EP-0133234-A2 | Imidazoquinazolin-2-one compounds process for their production and pharmaceutical compositions containing said compounds | DAIICHI SEIYAKU CO., LTD. (JP) | 1985-02-20 | — | — | EP | disclosed |
| EP-0133234-A2 | Imidazoquinazolin-2-one compounds process for their production and pharmaceutical compositions containing said compounds | DAIICHI SEIYAKU CO., LTD. (JP) | 1985-02-20 | — | — | EP | disclosed |