SCHEMBL8763446

SCHEMBL8763446

CC(N=C=S)[SiH](c1ccccc1)c1ccccc1

nearest known ligand 0.52

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
MIF P14174 6/20 0.52
TRPA1 O75762 4/20 0.36
TRPV1 Q8NER1 2/20 0.36
ALDH1A1 P00352 1/20 0.32
CYP3A4 P08684 1/20 0.32
HPGD P15428 1/20 0.32
CYP2E1 P05181 1/20 0.31
CYP2A6 P11509 1/20 0.31
HIF1A Q16665 1/20 0.31
CYP2A13 Q16696 1/20 0.31
EPAS1 Q99814 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28938422 0.72 MIF (0.43) MIFTRPA1TRPV1ALDH1A1CYP3A4
SCHEMBL8763920 0.69 MIF (0.64) MIFTRPA1TRPV1ALDH1A1CYP3A4
1-Phenylethyl Isothiocyanate SCHEMBL27811213 0.68 MIF (1.00) MIFTRPA1TRPV1ALDH1A1CYP3A4
1-Phenylethyl Isothiocyanate SCHEMBL156959 0.68 MIF (1.00) MIFTRPA1TRPV1ALDH1A1CYP3A4
1-Phenylethyl Isothiocyanate SCHEMBL3792824 0.68 MIF (1.00) MIFTRPA1TRPV1ALDH1A1CYP3A4
1-Phenylethyl Isothiocyanate SCHEMBL3795180 0.68 MIF (1.00) MIFTRPA1TRPV1ALDH1A1CYP3A4
SCHEMBL19136035 0.68 PDE2A (0.33)
SCHEMBL1325645 0.68 TDP1 (0.36) ALDH1A1CYP3A4CYP2A6HIF1A
SCHEMBL332408 0.66 MIF (0.65) MIFTRPA1TRPV1ALDH1A1CYP3A4
SCHEMBL15302680 0.64 TDP1 (0.33) CYP2A6HIF1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0349195-B1 Direct synthesis by cationic polymerization of nitrogen-containing polymers EXXON CHEMICAL PATENTS INC (US) 1997-05-21 EP disclosed
US-5629394-A ENDCAPPING ADDITION POLYMERS WITH NITROGEN FUNCTIONAL GROUPS WHICH CAN BE FURTHER DERIVATIZED EXXON CHEMICAL PATENTS INC (US) 1997-05-13 US disclosed
US-5444135-A Polymerization and functionalization with nitrogen-containing functional groups occur simultaneously EXXON CHEMICAL PATENTS INC. (US) 1995-08-22 US disclosed
US-5336745-A Terminally-substituted polymeric compositions from cationically polymerizable monomers and initiators EXXON CHEMICAL PATENTS INC. (US) 1994-08-09 US disclosed
US-5032653-A Catalysts EXXON CHEMICAL PATENTS, INC. (US) 1991-07-16 US disclosed
EP-0349195-A2 Direct synthesis by cationic polymerization of nitrogen-containing polymers EXXON CHEMICAL PATENTS INC. (US) 1990-01-03 EP disclosed