Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 4/20 | 0.68 |
| ▸ | DRD3 | P35462 | 3/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.67 |
| ▸ | ADRA1D | P25100 | 5/20 | 0.61 |
| ▸ | ADRA1A | P35348 | 5/20 | 0.61 |
| ▸ | ADRA1B | P35368 | 5/20 | 0.61 |
| ▸ | HTR1A | P08908 | 1/20 | 0.61 |
| ▸ | DRD4 | P21917 | 1/20 | 0.55 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8764445 | 1.00 | DRD2 (0.68) | DRD2DRD3KDM4EALDH1A1ADRA1D | |
| SCHEMBL8764218 | 1.00 | DRD2 (0.68) | DRD2DRD3KDM4EALDH1A1ADRA1D | |
| SCHEMBL8763698 | 0.89 | ALDH1A1 (0.73) | DRD2DRD3KDM4EALDH1A1ADRA1D | |
| SCHEMBL8763933 | 0.89 | ALDH1A1 (0.73) | DRD2DRD3KDM4EALDH1A1ADRA1D | |
| SCHEMBL8763945 | 0.89 | ALDH1A1 (0.73) | DRD2DRD3KDM4EALDH1A1ADRA1D | |
| SCHEMBL8763703 | 0.89 | ALDH1A1 (0.73) | DRD2DRD3KDM4EALDH1A1ADRA1D | |
| SCHEMBL8763716 | 0.89 | ALDH1A1 (0.73) | DRD2DRD3KDM4EALDH1A1ADRA1D | |
| SCHEMBL8764013 | 0.88 | KDM4E (0.84) | DRD2DRD3KDM4EALDH1A1ADRA1D | |
| SCHEMBL8764010 | 0.88 | KDM4E (0.84) | DRD2DRD3KDM4EALDH1A1ADRA1D | |
| SCHEMBL8763921 | 0.81 | KDM4E (0.73) | DRD2DRD3KDM4EALDH1A1ADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0677046-B1 | PIPERAZINE DERIVATIVES AS 5-HT ANTAGONISTS | WYETH JOHN & BROTHER LTD (GB) | 1997-07-09 | — | — | EP | claimed |
| US-5622951-A | Piperazine derivatives as 5-HT antagonists | JOHN WYETH & BROTHER LTD. (GB) | 1997-04-22 | — | — | US | claimed |
| EP-0677046-A1 | PIPERAZINE DERIVATIVES AS 5-HT ANTAGONISTS. | WYETH JOHN & BROTHER LTD (GB) | 1995-10-18 | — | — | EP | claimed |
| WO-1994015928-A1 | PIPERAZINE DERIVATIVES AS 5-HT ANTAGONISTS | JOHN WYETH & BROTHER LIMITED (GB) | 1994-07-21 | — | — | WO | claimed |
| EP-0677046-B1 | PIPERAZINE DERIVATIVES AS 5-HT ANTAGONISTS | WYETH JOHN & BROTHER LTD (GB) | 1997-07-09 | — | — | EP | disclosed |
| US-5622951-A | Piperazine derivatives as 5-HT antagonists | JOHN WYETH & BROTHER LTD. (GB) | 1997-04-22 | — | — | US | disclosed |