Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.51 |
| ▸ | MAOB | P27338 | 3/20 | 0.47 |
| ▸ | MAOA | P21397 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.41 |
| ▸ | FLT3 | P36888 | 1/20 | 0.41 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.41 |
| ▸ | MGLL | Q99685 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1419067 | 0.81 | KDM4E (0.45) | CYP2D6HIF1AMAOBMAOAALDH1A1 | |
| SCHEMBL456821 | 0.79 | ALDH1A1 (0.62) | MAOBMAOAALDH1A1LMNATHRB | |
| SCHEMBL456822 | 0.79 | ALDH1A1 (0.62) | MAOBMAOAALDH1A1LMNATHRB | |
| SCHEMBL28643561 | 0.79 | CYP2A6 (0.47) | CYP2D6HIF1AMAOBMAOAALDH1A1 | |
| Hydrochloric Acid SCHEMBL1116447 | 0.78 | ALDH1A1 (0.61) | MAOBMAOAALDH1A1LMNATHRB | |
| SCHEMBL162882 | 0.77 | NPC1 (0.52) | CYP2D6HIF1AMAOBMAOAALDH1A1 | |
| SCHEMBL7699924 | 0.75 | FLT3 (0.48) | CYP2D6HIF1AMAOBALDH1A1HSD17B10 | |
| SCHEMBL12626870 | 0.74 | CYP2D6 (0.46) | CYP2D6HIF1AMAOBMAOAALDH1A1 | |
| SCHEMBL178528 | 0.74 | CYP2D6 (0.50) | CYP2D6HIF1AMAOBMAOAALDH1A1 | |
| SCHEMBL18232971 | 0.74 | MAOA (0.46) | CYP2D6HIF1AMAOBMAOAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0775129-A1 | 3-BENZOYL BENZOFURAN DERIVATIVES AS THYROID HORMONE ANTAGONISTS | KARO BIO AB (SE) | 1997-05-28 | — | — | EP | disclosed |
| WO-1996005190-A1 | 3-BENZOYL BENZOFURAN DERIVATIVES AS THYROID HORMONE ANTAGONISTS | KARO BIO AB (SE) | 1996-02-22 | — | — | WO | disclosed |