Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AOC3 | Q16853 | 1/20 | 0.48 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8766177 | 0.96 | AOC3 (0.46) | AOC3PTGS2POLBHTTEPHX2 | |
| SCHEMBL8765030 | 0.95 | POLB (0.48) | AOC3PTGS2POLBHTTEPHX2 | |
| SCHEMBL8764387 | 0.91 | CA1 (0.51) | PTGS2CA12CA1CA2CA9 | |
| SCHEMBL8765507 | 0.88 | PTGS2 (0.43) | PTGS2 | |
| SCHEMBL8765313 | 0.87 | PTGS2 (0.48) | PTGS2POLBHTTCA12CA1 | |
| SCHEMBL8765550 | 0.87 | PTGS2 (0.46) | AOC3PTGS2 | |
| SCHEMBL8764490 | 0.86 | CA1 (0.48) | PTGS2POLBHTTCA12CA1 | |
| SCHEMBL8764467 | 0.85 | CCR1 (0.43) | AOC3PTGS2MAPT | |
| SCHEMBL8765491 | 0.85 | PTGS2 (0.47) | AOC3PTGS2KDM4EMAPT | |
| SCHEMBL8765351 | 0.83 | PTGS2 (0.43) | PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0731794-B1 | 1,4,5-TRIPHENYL PYRAZOLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION AND INFLAMMATION-RELATED DISORDERS | SEARLE & CO (US) | 1997-08-06 | — | — | EP | disclosed |
| US-5639777-A | 1,4,5-triphenyl pyrazolyl compounds for the treatment of inflammation and inflammation-related disorders | G.D. SEARLE & CO. (US) | 1997-06-17 | — | — | US | disclosed |
| US-5401765-A | FOR TREATING ARTHRITIS, PAIN AND FEVER | Searle, G. D. (US) | 1995-03-28 | — | — | US | disclosed |