Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 3/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.43 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.42 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.40 |
| ▸ | MMP13 | P45452 | 1/20 | 0.40 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.40 |
| ▸ | ELANE | P08246 | 3/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8765120 | 0.96 | EPHX2 (0.42) | CCR1PTGS2AOC3ADAMTS4MMP13 | |
| SCHEMBL8765529 | 0.95 | PTGS2 (0.41) | CCR1PTGS2AOC3ADAMTS4MMP13 | |
| SCHEMBL8765404 | 0.91 | PTGS2 (0.43) | PTGS2 | |
| SCHEMBL8764774 | 0.88 | PTGS2 (0.49) | PTGS2 | |
| SCHEMBL8765150 | 0.87 | PTGS2 (0.46) | PTGS2 | |
| SCHEMBL8765507 | 0.85 | PTGS2 (0.43) | PTGS2 | |
| SCHEMBL8765147 | 0.85 | AOC3 (0.48) | PTGS2AOC3MAPT | |
| SCHEMBL8765087 | 0.84 | PTGS2 (0.43) | PTGS2 | |
| SCHEMBL8765446 | 0.84 | GRIA2 (0.53) | CCR1PTGS2AOC3GRIA2 | |
| SCHEMBL8765491 | 0.82 | PTGS2 (0.47) | PTGS2AOC3TP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0731794-B1 | 1,4,5-TRIPHENYL PYRAZOLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION AND INFLAMMATION-RELATED DISORDERS | SEARLE & CO (US) | 1997-08-06 | — | — | EP | disclosed |
| US-5639777-A | 1,4,5-triphenyl pyrazolyl compounds for the treatment of inflammation and inflammation-related disorders | G.D. SEARLE & CO. (US) | 1997-06-17 | — | — | US | disclosed |
| US-5401765-A | FOR TREATING ARTHRITIS, PAIN AND FEVER | Searle, G. D. (US) | 1995-03-28 | — | — | US | disclosed |