Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 9/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 5/20 | 0.43 |
| ▸ | CA1 | P00915 | 9/20 | 0.42 |
| ▸ | CA2 | P00918 | 9/20 | 0.42 |
| ▸ | CA7 | P43166 | 2/20 | 0.42 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 5/20 | 0.41 |
| ▸ | CA4 | P22748 | 3/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8764774 | 0.96 | PTGS2 (0.49) | PTGS2PTGS1CA1CA2CA7 | |
| SCHEMBL8765150 | 0.95 | PTGS2 (0.46) | PTGS2PTGS1CA1CA2CA7 | |
| SCHEMBL8764467 | 0.91 | CCR1 (0.43) | PTGS2 | |
| SCHEMBL8765120 | 0.88 | EPHX2 (0.42) | PTGS2 | |
| SCHEMBL8765529 | 0.87 | PTGS2 (0.41) | PTGS2 | |
| SCHEMBL8764387 | 0.85 | CA1 (0.51) | PTGS2PTGS1CA1CA2CA7 | |
| SCHEMBL8765103 | 0.85 | PTGS2 (0.54) | PTGS2PTGS1CA1CA2CA9 | |
| SCHEMBL8765706 | 0.85 | PTGS2 (0.53) | PTGS2PTGS1CA1CA2CA7 | |
| SCHEMBL8765313 | 0.82 | PTGS2 (0.48) | PTGS2PTGS1CA1CA2CA7 | |
| SCHEMBL8765195 | 0.81 | PTGS2 (0.59) | PTGS2PTGS1CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0731794-B1 | 1,4,5-TRIPHENYL PYRAZOLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION AND INFLAMMATION-RELATED DISORDERS | SEARLE & CO (US) | 1997-08-06 | — | — | EP | disclosed |
| US-5639777-A | 1,4,5-triphenyl pyrazolyl compounds for the treatment of inflammation and inflammation-related disorders | G.D. SEARLE & CO. (US) | 1997-06-17 | — | — | US | disclosed |
| EP-0731794-A1 | 1,4,5-TRIPHENYL PYRAZOLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION AND INFLAMMATION-RELATED DISORDERS | SEARLE & CO (US) | 1996-09-18 | — | — | EP | disclosed |
| WO-1995015317-A1 | 1,4,5-TRIPHENYL PYRAZOLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION AND INFLAMMATION-RELATED DISORDERS | G.D. SEARLE & CO. (US) | 1995-06-08 | — | — | WO | disclosed |