Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 14/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8765778 | 0.97 | ALOX5 (0.48) | PTGS2PTGS1CYP2C9ALOX5 | |
| SCHEMBL8672399 | 0.94 | PTGS2 (0.51) | PTGS2PTGS1ALOX5 | |
| SCHEMBL8765305 | 0.94 | PTGS2 (0.51) | PTGS2PTGS1CYP2C9 | |
| SCHEMBL8638385 | 0.91 | PTGS2 (0.48) | PTGS2PTGS1 | |
| Dimethylamine SCHEMBL8765691 | 0.91 | PTGS2 (0.48) | PTGS2PTGS1ALOX5 | |
| SCHEMBL8764443 | 0.90 | PTGS2 (0.46) | PTGS2PTGS1 | |
| SCHEMBL8765686 | 0.90 | PTGS2 (0.47) | PTGS2PTGS1ALOX5 | |
| SCHEMBL8765169 | 0.90 | PTGS2 (0.45) | PTGS2PTGS1CYP2C9ALOX5 | |
| SCHEMBL8766379 | 0.90 | PTGS2 (0.45) | PTGS2PTGS1ALOX5 | |
| SCHEMBL8766207 | 0.90 | PTGS2 (0.45) | PTGS2PTGS1CYP2C9ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0731794-B1 | 1,4,5-TRIPHENYL PYRAZOLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION AND INFLAMMATION-RELATED DISORDERS | SEARLE & CO (US) | 1997-08-06 | — | — | EP | disclosed |
| US-5639777-A | 1,4,5-triphenyl pyrazolyl compounds for the treatment of inflammation and inflammation-related disorders | G.D. SEARLE & CO. (US) | 1997-06-17 | — | — | US | disclosed |
| EP-0731794-A1 | 1,4,5-TRIPHENYL PYRAZOLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION AND INFLAMMATION-RELATED DISORDERS | SEARLE & CO (US) | 1996-09-18 | — | — | EP | disclosed |
| WO-1995015317-A1 | 1,4,5-TRIPHENYL PYRAZOLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION AND INFLAMMATION-RELATED DISORDERS | G.D. SEARLE & CO. (US) | 1995-06-08 | — | — | WO | disclosed |
| US-5401765-A | FOR TREATING ARTHRITIS, PAIN AND FEVER | Searle, G. D. (US) | 1995-03-28 | — | — | US | disclosed |