SCHEMBL8765953

SCHEMBL8765953

CC1(C)CCSc2ccc(C#Cc3ccc(CCO)cn3)cc21

nearest known ligand 0.67

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 3/20 0.67
CYP26A1 O43174 2/20 0.67
RARA P10276 10/20 0.64
RARB P10826 10/20 0.64
RARG P13631 10/20 0.64
KMT2A Q03164 1/20 0.64
FFAR1 O14842 1/20 0.37
FFAR4 Q5NUL3 1/20 0.37
ACACB O00763 2/20 0.36
RXRA P19793 2/20 0.34
BACE1 P56817 4/20 0.34
BACE2 Q9Y5Z0 4/20 0.34
SSTR5 P35346 1/20 0.34
CRABP2 P29373 1/20 0.33
MCHR1 Q99705 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL860637 0.92 CYP3A4 (0.69) CYP3A4CYP26A1RARARARBRARG
SCHEMBL30374281 0.92 CYP3A4 (0.69) CYP3A4CYP26A1RARARARBRARG
SCHEMBL6670285 0.86 CYP26A1 (0.73) CYP3A4CYP26A1RARARARBRARG
SCHEMBL17885757 0.82 CYP3A4 (0.71) CYP3A4CYP26A1RARARARBRARG
SCHEMBL6671541 0.82 RARA (0.70) CYP3A4CYP26A1RARARARBRARG
SCHEMBL180442 0.82 CYP3A4 (0.70) CYP3A4CYP26A1RARARARBRARG
SCHEMBL5485071 0.81 CYP3A4 (0.70) CYP3A4CYP26A1RARARARBRARG
SCHEMBL6665694 0.81 CYP3A4 (0.70) CYP3A4CYP26A1RARARARBRARG
SCHEMBL8765958 0.80 CYP3A4 (0.68) CYP3A4CYP26A1RARARARBRARG
SCHEMBL14330777 0.80 CYP3A4 (0.84) CYP3A4CYP26A1RARARARBRARG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0785782-A1 DISUBSTITUTED ACETYLENES BEARING HETEROAROMATIC AND HETEROBICYCLIC GROUPS HAVING RETINOID-LIKE ACTIVITY Allergan (US) 1997-07-30 EP disclosed
WO-1996011686-A1 DISUBSTITUTED ACETYLENES BEARING HETEROAROMATIC AND HETEROBICYCLIC GROUPS HAVING RETINOID-LIKE ACTIVITY ALLERGAN (US) 1996-04-25 WO disclosed