SCHEMBL8766281

SCHEMBL8766281

CC(=O)Nc1cccc([O])c1NC(C)=O

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.52
HPGD P15428 3/20 0.52
MAOA P21397 1/20 0.46
CYP2C19 P33261 2/20 0.46
POLB P06746 1/20 0.46
CYP1A2 P05177 2/20 0.45
KDM4E B2RXH2 2/20 0.45
KMT2A Q03164 2/20 0.45
CYP3A4 P08684 1/20 0.45
CYP2D6 P10635 1/20 0.45
CYP2C9 P11712 1/20 0.45
GAA P10253 1/20 0.45
HSD17B10 Q99714 1/20 0.45
MEN1 O00255 1/20 0.45
MAPK1 P28482 1/20 0.44
NPC1 O15118 1/20 0.44
RAB9A P51151 1/20 0.44
TSHR P16473 2/20 0.43
MAPT P10636 1/20 0.43
HTT P42858 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL958841 0.81 ALDH1A1 (0.63) ALDH1A1HPGDMAOACYP2C19POLB
SCHEMBL249105 0.80 ALDH1A1 (0.52) ALDH1A1HPGDMAOACYP2C19POLB
SCHEMBL11424223 0.80 ALDH1A1 (0.68) ALDH1A1HPGDMAOACYP2C19POLB
SCHEMBL10689500 0.78 ALDH1A1 (0.50) ALDH1A1HPGDMAOACYP2C19POLB
SCHEMBL3785379 0.78 ALDH1A1 (0.50) ALDH1A1HPGDMAOACYP2C19POLB
SCHEMBL8677789 0.78 ALDH1A1 (0.50) ALDH1A1HPGDMAOACYP2C19POLB
SCHEMBL11519154 0.78 CYP2C19 (0.53) ALDH1A1HPGDMAOACYP2C19POLB
SCHEMBL1805658 0.78 RXFP1 (0.56) ALDH1A1HPGDMAOACYP2C19POLB
SCHEMBL5685862 0.78 ALDH1A1 (0.46) ALDH1A1HPGDMAOACYP2C19POLB
SCHEMBL3655894 0.77 POLB (0.56) ALDH1A1HPGDMAOACYP2C19POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0778267-A1 SULFONAMIDE DERIVATIVES AND INSECTICIDE, MITICIDE AND NEMATICIDE CONTAINING THE SAME OTSUKA KAGAKU KABUSHIKI KAISHA (JP) 1997-06-11 EP disclosed