Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR4 | Q13639 | 1/20 | 0.51 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.48 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.48 |
| ▸ | FUCA1 | P04066 | 2/20 | 0.46 |
| ▸ | NPY2R | P49146 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.45 |
| ▸ | DRD4 | P21917 | 1/20 | 0.45 |
| ▸ | DRD3 | P35462 | 1/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.45 |
| ▸ | TEAD1 | P28347 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6177077 | 0.87 | HTR4 (0.47) | HTR4S1PR1S1PR5KMT2AMEN1 | |
| SCHEMBL4073432 | 0.87 | HTR4 (0.47) | HTR4S1PR1S1PR5KMT2AMEN1 | |
| SCHEMBL4073113 | 0.87 | HTR4 (0.47) | HTR4S1PR1S1PR5KMT2AMEN1 | |
| SCHEMBL4898687 | 0.84 | HTR4 (0.54) | HTR4S1PR1S1PR5FUCA1KMT2A | |
| SCHEMBL5948027 | 0.83 | CHRM3 (0.49) | HTR4S1PR1S1PR5 | |
| SCHEMBL8919552 | 0.82 | KMT2A (0.57) | HTR4S1PR1S1PR5FUCA1KMT2A | |
| SCHEMBL4618393 | 0.82 | HTR4 (0.46) | HTR4S1PR1S1PR5TEAD1 | |
| SCHEMBL4619381 | 0.80 | CHRM2 (0.49) | HTR4S1PR1S1PR5GAA | |
| SCHEMBL4001399 | 0.79 | SIGMAR1 (0.50) | HTR4S1PR1S1PR5FUCA1KMT2A | |
| SCHEMBL5948239 | 0.79 | CHRM2 (0.65) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0629189-B1 | PREPARATION OF INTERMEDIATES IN THE SYNTHESIS OF QUINOLINE ANTIBIOTICS | PFIZER (US) | 1997-08-06 | — | — | EP | disclosed |
| US-5298629-A | Intermediates in the synthesis of quinoline antibiotics | PFIZER INC. (US) | 1994-03-29 | — | — | US | disclosed |
| US-5256791-A | Preparation of intermediates in the synthesis of quinoline antibiotics | PFIZER INC. (US) | 1993-10-26 | — | — | US | disclosed |