Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 4/20 | 0.48 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | F2R | P25116 | 3/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8766983 | 0.90 | HMGCR (0.45) | HMGCRNR1I2KMT2AMEN1GAA | |
| SCHEMBL8766713 | 0.88 | HMGCR (0.44) | HMGCRNR1I2KMT2AMEN1GAA | |
| SCHEMBL8766044 | 0.88 | HMGCR (0.43) | HMGCRNR1I2KMT2AMEN1GAA | |
| SCHEMBL8609257 | 0.88 | HMGCR (0.43) | HMGCRNR1I2KMT2AMEN1GAA | |
| SCHEMBL8766672 | 0.87 | HMGCR (0.43) | HMGCRNR1I2KMT2AMEN1GAA | |
| SCHEMBL8766583 | 0.87 | HMGCR (0.43) | HMGCRNR1I2KMT2AMEN1GAA | |
| SCHEMBL7120195 | 0.86 | HMGCR (0.43) | HMGCRNR1I2KMT2AMEN1GAA | |
| SCHEMBL8767341 | 0.86 | HMGCR (0.43) | HMGCRNR1I2KMT2AMEN1GAA | |
| SCHEMBL7125857 | 0.85 | HMGCR (0.41) | HMGCRNR1I2KMT2AMEN1GAA | |
| SCHEMBL8766474 | 0.83 | HMGCR (0.42) | HMGCRNR1I2LMNARECQLCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0559079-B1 | Substituted aminophosphonate derivatives, process for their preparation and pharmaceutical compositions containing them | SYMPHAR SA (CH) | 1997-08-13 | — | — | EP | claimed |
| EP-0559079-A1 | Substituted aminophosphonate derivatives, process for their preparation and pharmaceutical compositions containing them | SYMPHAR S.A. (CH) | 1993-09-08 | — | — | EP | claimed |