Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 3/20 | 0.43 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | RECQL | P46063 | 2/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | PLK1 | P53350 | 1/20 | 0.33 |
| ▸ | LTA4H | P09960 | 1/20 | 0.33 |
| ▸ | NQO1 | P15559 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8766672 | 0.91 | HMGCR (0.43) | HMGCRNR1I2LMNARECQLMEN1 | |
| SCHEMBL8766983 | 0.89 | HMGCR (0.45) | HMGCRNR1I2LMNARECQLPTGS1 | |
| SCHEMBL8766723 | 0.88 | HMGCR (0.39) | HMGCRNR1I2LMNARECQLPTGS1 | |
| SCHEMBL8767341 | 0.88 | HMGCR (0.43) | HMGCRNR1I2LMNARECQLPTGS1 | |
| SCHEMBL8766044 | 0.87 | HMGCR (0.43) | HMGCRNR1I2LMNARECQLPTGS1 | |
| SCHEMBL8766643 | 0.87 | HMGCR (0.48) | HMGCRNR1I2LMNARECQLPTGS2 | |
| SCHEMBL8609257 | 0.85 | HMGCR (0.43) | HMGCRNR1I2LMNARECQLPTGS1 | |
| SCHEMBL8766474 | 0.82 | HMGCR (0.42) | HMGCRNR1I2LMNARECQLPTGS1 | |
| SCHEMBL8766713 | 0.81 | HMGCR (0.44) | HMGCRNR1I2LMNARECQLMEN1 | |
| SCHEMBL7125857 | 0.80 | HMGCR (0.41) | HMGCRNR1I2LMNARECQLPTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0559079-B1 | Substituted aminophosphonate derivatives, process for their preparation and pharmaceutical compositions containing them | SYMPHAR SA (CH) | 1997-08-13 | — | — | EP | claimed |
| EP-0559079-A1 | Substituted aminophosphonate derivatives, process for their preparation and pharmaceutical compositions containing them | SYMPHAR S.A. (CH) | 1993-09-08 | — | — | EP | claimed |