SCHEMBL8766741

SCHEMBL8766741

COC(=O)C(=NOCF)c1ccccc1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.43
SMN1; SMN2 Q16637 2/20 0.42
MAPK1 P28482 2/20 0.39
LMNA P02545 2/20 0.39
L3MBTL1 Q9Y468 2/20 0.39
HTT P42858 1/20 0.39
KMT2A Q03164 2/20 0.38
HPGD P15428 3/20 0.38
HIF1A Q16665 2/20 0.38
CES1 P23141 2/20 0.37
MAPT P10636 2/20 0.37
KDM4E B2RXH2 1/20 0.37
MEN1 O00255 1/20 0.37
CYP3A4 P08684 1/20 0.37
ALOX15 P16050 1/20 0.37
TDP1 Q9NUW8 1/20 0.37
SRC P12931 1/20 0.37
NPC1 O15118 1/20 0.36
CES2 O00748 1/20 0.36
ACHE P22303 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28574555 0.85 SMN1; SMN2 (0.50) TSHRSMN1; SMN2MAPK1LMNAL3MBTL1
SCHEMBL27446293 0.81 TSHR (0.50) TSHRSMN1; SMN2MAPK1LMNAL3MBTL1
SCHEMBL7457347 0.81 TSHR (0.50) TSHRSMN1; SMN2MAPK1LMNAL3MBTL1
SCHEMBL7217221 0.80 LMNA (0.47) TSHRSMN1; SMN2LMNAL3MBTL1HTT
SCHEMBL7217224 0.80 LMNA (0.47) TSHRSMN1; SMN2LMNAL3MBTL1HTT
SCHEMBL7215595 0.77 HIF1A (0.46) TSHRSMN1; SMN2LMNAHPGDHIF1A
SCHEMBL8766703 0.77 HIF1A (0.46) TSHRSMN1; SMN2LMNAHPGDHIF1A
SCHEMBL8061864 0.77 HIF1A (0.46) TSHRLMNAHPGDHIF1AKDM4E
SCHEMBL6025444 0.75 GAA (0.57) TSHRSMN1; SMN2MAPK1LMNAL3MBTL1
SCHEMBL6025442 0.75 GAA (0.57) TSHRSMN1; SMN2MAPK1LMNAL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0777645-A1 OXIME ETHERS AND THEIR USE AS PESTICIDES Novartis AG (CH) 1997-06-11 EP disclosed
WO-1996006072-A1 OXIME ETHERS AND THEIR USE AS PESTICIDES CIBA-GEIGY AG (CH) 1996-02-29 WO disclosed