SCHEMBL8766757

SCHEMBL8766757

CC1(c2cc(CC=O)ccc2O[Si](C)(C)C(C)(C)C)CCCCC1

nearest known ligand 0.38

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
PTGDR Q13258 1/20 0.38
PTGDR2 Q9Y5Y4 1/20 0.38
RARA P10276 2/20 0.34
RARB P10826 2/20 0.34
RARG P13631 2/20 0.34
DRD2 P14416 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8766888 0.83 RARA (0.40) PTGDRPTGDR2RARARARBRARG
SCHEMBL7683187 0.81 RARA (0.49) PTGDRPTGDR2RARARARBRARG
SCHEMBL6619475 0.80 PTGDR (0.37) PTGDRPTGDR2RARARARBRARG
SCHEMBL8766851 0.78 S1PR1 (0.37) RARARARBRARGDRD2
SCHEMBL9077146 0.77 RARB (0.54) PTGDRPTGDR2RARARARBRARG
SCHEMBL8766766 0.77 RARB (0.47) PTGDRPTGDR2RARARARBRARG
SCHEMBL6138549 0.74 DRD2 (0.54) DRD2
SCHEMBL6314028 0.74 DRD2 (0.38) DRD2
SCHEMBL8766282 0.73 RARB (0.53) PTGDRPTGDR2RARARARBRARG
SCHEMBL8766289 0.73 RARB (0.53) PTGDRPTGDR2RARARARBRARG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0584191-B1 NOVEL AROMATIC AND POLYCYCLIC COMPOUNDS AND THEIR USE IN HUMAN OR VETERINARY MEDICINE AND IN COSMETICS CIRD GALDERMA (FR) 1997-08-13 EP disclosed
US-5547983-A Aromatic and polycyclic compounds and their use in human or veterinary medicine and in cosmetics CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (CIRD GALDERMA) (FR) 1996-08-20 US disclosed
EP-0584191-A1 NOVEL AROMATIC AND POLYCYCLIC COMPOUNDS AND THEIR USE IN HUMAN OR VETERINARY MEDECINE AND IN COSMETICS. CIRD GALDERMA (FR) 1994-03-02 EP disclosed
WO-1992019583-A1 NOVEL AROMATIC AND POLYCYCLIC COMPOUNDS AND THEIR USE IN HUMAN OR VETERINARY MEDECINE AND IN COSMETICS CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (CIRD GALDERMA) (FR) 1992-11-12 WO disclosed