Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE1A | P54750 | 13/20 | 1.00 |
| ▸ | PDE1B | Q01064 | 13/20 | 1.00 |
| ▸ | PDE1C | Q14123 | 13/20 | 1.00 |
| ▸ | ESR1 | P03372 | 6/20 | 0.88 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.88 |
| ▸ | PSMB1 | P20618 | 3/20 | 0.77 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.77 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.77 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8767419 | 0.98 | PDE1A (1.00) | PDE1APDE1BPDE1CESR1ESR2 | |
| SCHEMBL8767418 | 0.98 | PDE1A (1.00) | PDE1APDE1BPDE1CESR1ESR2 | |
| SCHEMBL8767423 | 0.98 | PDE1A (1.00) | PDE1APDE1BPDE1CESR1ESR2 | |
| Idoxifene SCHEMBL19217 | 0.93 | PDE1A (1.00) | PDE1APDE1BPDE1CESR1ESR2 | |
| Idoxifene SCHEMBL19216 | 0.93 | PDE1A (1.00) | PDE1APDE1BPDE1CESR1ESR2 | |
| Idoxifene SCHEMBL3774574 | 0.93 | PDE1A (1.00) | PDE1APDE1BPDE1CESR1ESR2 | |
| SCHEMBL23266947 | 0.92 | ESR1 (0.90) | PDE1APDE1BPDE1CESR1ESR2 | |
| SCHEMBL7650153 | 0.87 | PSMB1 (1.00) | PDE1APDE1BPDE1CESR1ESR2 | |
| SCHEMBL30902018 | 0.87 | PSMB1 (1.00) | PDE1APDE1BPDE1CESR1ESR2 | |
| SCHEMBL29822053 | 0.87 | PSMB1 (1.00) | PDE1APDE1BPDE1CESR1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0638064-B1 | SUBSTITUTED 1,1,2-TRIPHENYLBUTENES AND THEIR USE IN THE TREATMENT AND DIAGNOSIS OF CANCER | BRITISH TECH GROUP (GB) | 1997-08-13 | — | — | EP | disclosed |
| US-5589500-A | TREATMENT OF TUMORS OR ANTICARCINOGENIC AGENTS | BRITISH TECHNOLOGY GROUP LIMITED (GB) | 1996-12-31 | — | — | US | disclosed |
| WO-1993022275-A1 | SUBSTITUTED 1,1,2-TRIPHENYLBUTENES AND THEIR USE IN THE TREATMENT AND DIAGNOSIS OF CANCER | BRITISH TECHNOLOGY GROUP LTD (GB) | 1993-11-11 | — | — | WO | disclosed |