Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.59 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | APEX1 | P27695 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17727833 | 0.94 | TSHR (0.56) | TSHRTHRBPOLBAPEX1HTT | |
| SCHEMBL3898618 | 0.87 | TSHR (0.58) | TSHRTHRBPOLBAPEX1HTT | |
| SCHEMBL9859598 | 0.86 | TSHR (0.51) | TSHRTHRBPOLBAPEX1HTT | |
| SCHEMBL9706878 | 0.86 | TSHR (0.56) | TSHRTHRBPOLBAPEX1HTT | |
| SCHEMBL29035611 | 0.86 | TSHR (0.61) | TSHRTHRBPOLBAPEX1HTT | |
| SCHEMBL5144090 | 0.84 | TSHR (0.79) | TSHRTHRBPOLBAPEX1HTT | |
| SCHEMBL25426 | 0.84 | TSHR (0.79) | TSHRTHRBPOLBAPEX1HTT | |
| SCHEMBL31438968 | 0.83 | TSHR (0.62) | TSHRTHRBPOLBAPEX1HTT | |
| SCHEMBL3738577 | 0.83 | TSHR (0.62) | TSHRTHRBPOLBAPEX1HTT | |
| SCHEMBL6761585 | 0.83 | TSHR (0.49) | TSHRTHRBPOLBAPEX1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0611367-B1 | NOVEL UV CURABLE CROSSLINKING AGENTS USEFUL IN COPOLYMERIZATION | BAUSCH & LOMB (US) | 1997-06-25 | — | — | EP | disclosed |
| EP-0603268-B1 | WETTABLE SILICONE HYDROGEL COMPOSITIONS AND METHODS | BAUSCH & LOMB (US) | 1996-12-18 | — | — | EP | disclosed |
| EP-0611380-B1 | WETTABLE SILICONE HYDROGEL COMPOSITIONS AND METHODS FOR THEIR MANUFACTURE | BAUSCH & LOMB (US) | 1996-06-19 | — | — | EP | disclosed |
| US-5512205-A | BIOMEDICAL ARTICLES, CONTACT LENSES | BAUSCH & LOMB INCORPORATED (US) | 1996-04-30 | — | — | US | disclosed |
| US-5451617-A | Wettable silicone hydrogel compositions and methods for their manufacture | BAUSCH & LOMB INCORPORATED (US) | 1995-09-19 | — | — | US | disclosed |
| US-5449729-A | Vinyl monomer and crosslinking agent and acrylates with styrene | BAUSCH & LOMB INCORPORATED (US) | 1995-09-12 | — | — | US | disclosed |
| US-5352714-A | Curing and hydrating an unsaturated oxazolone monomer, a polysiloxane having acrylated end groups and an unsaturated monomer; contact lenses | BAUSCH & LOMB INCORPORATED (US) | 1994-10-04 | — | — | US | disclosed |
| EP-0611367-A1 | NOVEL UV CURABLE CROSSLINKING AGENTS USEFUL IN COPOLYMERIZATION. | BAUSCH & LOMB (US) | 1994-08-24 | — | — | EP | disclosed |
| EP-0611380-A1 | WETTABLE SILICONE HYDROGEL COMPOSITIONS AND METHODS FOR THEIR MANUFACTURE. | BAUSCH & LOMB (US) | 1994-08-24 | — | — | EP | disclosed |
| EP-0603268-A1 | WETTABLE SILICONE HYDROGEL COMPOSITIONS AND METHODS. | BAUSCH & LOMB (US) | 1994-06-29 | — | — | EP | disclosed |
| EP-0603270-A1 | WETTABLE SILICONE HYDROGEL COMPOSITIONS AND METHODS FOR MAKING THEM | BAUSCH & LOMB INCORPORATED (US) | 1994-06-29 | — | — | EP | disclosed |
| US-5310779-A | Compatible crosslinkers having vinyl-, acrylic-and/or styrenyl-groups to crosslink incompatible unsaturated addition monomers; contact lens; molding materials | BAUSCH & LOMB INCORPORATED (US) | 1994-05-10 | — | — | US | disclosed |
| WO-1993009084-A1 | NOVEL UV CURABLE CROSSLINKING AGENTS USEFUL IN COPOLYMERIZATION | BAUSCH & LOMB INCORPORATED (US) | 1993-05-13 | — | — | WO | disclosed |
| WO-1993009155-A1 | WETTABLE SILICONE HYDROGEL COMPOSITIONS AND METHODS FOR THEIR MANUFACTURE | BAUSCH & LOMB INCORPORATED (US) | 1993-05-13 | — | — | WO | disclosed |
| WO-1993005098-A1 | WETTABLE SILICONE HYDROGEL COMPOSITIONS AND METHODS | BAUSCH & LOMB INCORPORATED (US) | 1993-03-18 | — | — | WO | disclosed |
| WO-1993005085-A1 | WETTABLE SILICONE HYDROGEL COMPOSITIONS AND METHODS | BAUSCH & LOMB INCORPORATED (US) | 1993-03-18 | — | — | WO | disclosed |