Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SOAT1 | P35610 | 3/20 | 0.48 |
| ▸ | PPARG | P37231 | 5/20 | 0.46 |
| ▸ | PPARA | Q07869 | 5/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | PPARD | Q03181 | 2/20 | 0.40 |
| ▸ | SOAT2 | O75908 | 2/20 | 0.40 |
| ▸ | GUSB | P08236 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | FBP1 | P09467 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8768928 | 0.84 | SOAT1 (0.44) | SOAT1PPARGPPARAHDAC3HDAC1 | |
| SCHEMBL8925558 | 0.84 | PPARA (0.40) | SOAT1PPARGPPARAHDAC3HDAC1 | |
| SCHEMBL8768643 | 0.83 | ALDH1A1 (0.46) | SOAT1PPARGPPARAEGFRFBP1 | |
| SCHEMBL8925673 | 0.83 | HDAC1 (0.44) | SOAT1PPARGPPARAHDAC3HDAC1 | |
| SCHEMBL8768879 | 0.78 | PPARA (0.49) | SOAT1PPARGPPARAHDAC3HDAC1 | |
| SCHEMBL8767877 | 0.78 | HDAC6 (0.59) | SOAT1PPARGPPARAHDAC3HDAC1 | |
| SCHEMBL8768932 | 0.78 | HDAC6 (0.50) | SOAT1PPARGPPARAHDAC3HDAC1 | |
| SCHEMBL8768601 | 0.77 | PPARG (0.70) | SOAT1PPARGPPARAPPARDSOAT2 | |
| SCHEMBL8767691 | 0.77 | PPARA (0.50) | SOAT1PPARGPPARAHDAC3HDAC1 | |
| SCHEMBL8768853 | 0.77 | HDAC6 (0.49) | SOAT1PPARGPPARAHDAC3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0639178-B1 | ANTI-ATHEROSCLEROTIC ARYL COMPOUNDS | WELLCOME FOUND (GB) | 1997-09-03 | — | — | EP | disclosed |
| US-5658944-A | ANTICHOLESTEROL AGENTS | THE UNIVERSITY OF SOUTH CAROLINA (US) | 1997-08-19 | — | — | US | disclosed |
| EP-0639178-A1 | ANTI-ATHEROSCLEROTIC ARYL COMPOUNDS. | WELLCOME FOUND (GB) | 1995-02-22 | — | — | EP | disclosed |
| WO-1992010468-A1 | ANTI-ATHEROSCLEROTIC ARYL COMPOUNDS | THE WELLCOME FOUNDATION LIMITED (GB) | 1992-06-25 | — | — | WO | disclosed |