Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 14/20 | 0.68 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8768014 | 0.99 | BCHE (0.69) | BCHEMAPTTP53SMN1; SMN2ACHE | |
| SCHEMBL8768007 | 0.88 | BCHE (0.68) | BCHEMAPTTP53SMN1; SMN2ACHE | |
| SCHEMBL8767439 | 0.88 | BCHE (0.68) | BCHEMAPTTP53SMN1; SMN2ACHE | |
| SCHEMBL17614079 | 0.84 | NOX1 (0.67) | BCHEMAPTACHENOX1ALOX12 | |
| SCHEMBL8739119 | 0.82 | BCHE (1.00) | BCHEMAPTTP53SMN1; SMN2ACHE | |
| SCHEMBL8767420 | 0.79 | BCHE (0.75) | BCHEMAPTTP53SMN1; SMN2ACHE | |
| SCHEMBL28498255 | 0.74 | NOX1 (0.67) | BCHEMAPTACHENOX1ALOX12 | |
| SCHEMBL9185337 | 0.74 | MAPT (0.40) | BCHEMAPTACHENOX1ALOX12 | |
| SCHEMBL15237151 | 0.72 | BCHE (0.63) | BCHEMAPTALOX12 | |
| SCHEMBL9184458 | 0.72 | MAPT (0.41) | BCHEMAPTACHENOX1ALOX12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0499126-B1 | Process for the direct and regioselective functionalization in position 2 of phenothiazine | ZAMBON SPA (IT) | 1997-08-20 | — | — | EP | disclosed |
| US-5362871-A | Process for the direct and regioselective functionalization in position 2 of phenothiazine | ZAMBON GROUP S.P.A. (IT) | 1994-11-08 | — | — | US | disclosed |
| EP-0499126-A2 | Process for the direct and regioselective functionalization in position 2 of phenothiazine | ZAMBON GROUP S.p.A. (IT) | 1992-08-19 | — | — | EP | disclosed |