Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 13/20 | 0.68 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8768014 | 0.89 | BCHE (0.69) | BCHEMAPTTP53SMN1; SMN2ACHE | |
| SCHEMBL8767439 | 0.88 | BCHE (0.68) | BCHEMAPTTP53SMN1; SMN2ACHE | |
| SCHEMBL8768003 | 0.88 | BCHE (0.68) | BCHEMAPTTP53SMN1; SMN2ACHE | |
| SCHEMBL8739119 | 0.82 | BCHE (1.00) | BCHEMAPTTP53SMN1; SMN2ACHE | |
| SCHEMBL8767420 | 0.79 | BCHE (0.75) | BCHEMAPTTP53SMN1; SMN2ACHE | |
| SCHEMBL17614079 | 0.74 | NOX1 (0.67) | BCHEMAPTACHENOX1ALOX12 | |
| SCHEMBL28498255 | 0.74 | NOX1 (0.67) | BCHEMAPTACHENOX1ALOX12 | |
| SCHEMBL15237151 | 0.72 | BCHE (0.63) | BCHEMAPTALOX12KDM4E | |
| SCHEMBL9185325 | 0.72 | MAPT (0.39) | BCHEMAPTACHENOX1ALOX12 | |
| SCHEMBL28905465 | 0.71 | DRD2 (0.49) | BCHEMAPTACHENOX1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0499126-B1 | Process for the direct and regioselective functionalization in position 2 of phenothiazine | ZAMBON SPA (IT) | 1997-08-20 | — | — | EP | disclosed |
| US-5362871-A | Process for the direct and regioselective functionalization in position 2 of phenothiazine | ZAMBON GROUP S.P.A. (IT) | 1994-11-08 | — | — | US | disclosed |
| EP-0499126-A2 | Process for the direct and regioselective functionalization in position 2 of phenothiazine | ZAMBON GROUP S.p.A. (IT) | 1992-08-19 | — | — | EP | disclosed |