Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | BCHE | P06276 | 5/20 | 0.38 |
| ▸ | DRD2 | P14416 | 3/20 | 0.38 |
| ▸ | HRH1 | P35367 | 3/20 | 0.38 |
| ▸ | DRD3 | P35462 | 3/20 | 0.38 |
| ▸ | ACHE | P22303 | 2/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.38 |
| ▸ | HTR1A | P08908 | 2/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.38 |
| ▸ | DRD1 | P21728 | 2/20 | 0.38 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9184458 | 0.99 | MAPT (0.41) | MAPTALOX12NPSR1HTTLMNA | |
| SCHEMBL9186707 | 0.84 | MAPT (0.39) | MAPTALOX12NPSR1HTTLMNA | |
| SCHEMBL9185325 | 0.84 | MAPT (0.39) | MAPTALOX12NPSR1HTTLMNA | |
| SCHEMBL627990 | 0.78 | MAOA (0.52) | LMNABCHEACHENOX1 | |
| SCHEMBL17614079 | 0.75 | NOX1 (0.67) | MAPTALOX12NPSR1HTTLMNA | |
| SCHEMBL13938144 | 0.75 | BCHE (0.54) | MAPTLMNACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL8768003 | 0.74 | BCHE (0.68) | MAPTALOX12NPSR1HTTBCHE | |
| SCHEMBL7360175 | 0.73 | TSHR (0.46) | MAPTALOX12NPSR1HTTLMNA | |
| SCHEMBL28053770 | 0.73 | NOX1 (0.68) | MAPTHTTLMNACYP1A2CYP2D6 | |
| SCHEMBL8768014 | 0.72 | BCHE (0.69) | MAPTALOX12NPSR1HTTBCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0451675-B1 | Process for the direct and regioselective functionalization in position 2 of phenothiazine | ZAMBON SPA (IT) | 1995-11-02 | — | — | EP | disclosed |
| US-5089613-A | Sulfonation of N-acylphenothiazine with sulfuric acid, oleum or chlorosulfonic acid then reduciton to mercaptan and S-alkylation | ZAMBON GROUP S.P.A. (IT) | 1992-02-18 | — | — | US | disclosed |
| EP-0451675-A1 | Process for the direct and regioselective functionalization in position 2 of phenothiazine | ZAMBON GROUP S.p.A. (IT) | 1991-10-16 | — | — | EP | disclosed |