Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 11/20 | 0.47 |
| ▸ | AR | P10275 | 9/20 | 0.47 |
| ▸ | LMNA | P02545 | 4/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.47 |
| ▸ | ESR1 | P03372 | 2/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.47 |
| ▸ | NR3C1 | P04150 | 11/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.42 |
| ▸ | ABCB11 | O95342 | 3/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | SHBG | P04278 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8768225 | 1.00 | PGR (0.47) | PGRARLMNASLC6A4ESR1 | |
| SCHEMBL8768205 | 0.91 | NR3C1 (0.45) | PGRARLMNASLC6A4ESR1 | |
| SCHEMBL8768965 | 0.91 | NR3C1 (0.45) | PGRARLMNASLC6A4ESR1 | |
| SCHEMBL8767959 | 0.90 | NR3C1 (0.46) | PGRARLMNASLC6A4ESR1 | |
| SCHEMBL8768908 | 0.90 | NR3C1 (0.46) | PGRARLMNASLC6A4ESR1 | |
| SCHEMBL8767815 | 0.86 | PGR (0.49) | PGRARLMNASLC6A4ESR1 | |
| SCHEMBL8768832 | 0.86 | NR3C1 (0.45) | PGRARLMNASLC6A4ESR1 | |
| SCHEMBL8768230 | 0.86 | NR3C1 (0.45) | PGRARLMNASLC6A4ESR1 | |
| SCHEMBL8767750 | 0.85 | PGR (0.31) | PGRARLMNASLC6A4ESR1 | |
| SCHEMBL5502772 | 0.85 | NR3C1 (0.44) | PGRARLMNASLC6A4ESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0567469-B1 | 14beta-H-, 14- AND 15-EN-11beta-ARYL-4-ESTRENES | SCHERING AG (DE) | 1997-08-27 | — | — | EP | claimed |
| US-5426102-A | Antigestagenic, antiandrogenic, antiglucocorticoid, antimineralcorticoid properties | SCHERING AKTIENGESELLSCHAFT (DE) | 1995-06-20 | — | — | US | disclosed |