Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 10/20 | 0.44 |
| ▸ | PPARG | P37231 | 4/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.41 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.40 |
| ▸ | PPARD | Q03181 | 3/20 | 0.39 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | LTB4R2 | Q9NPC1 | 2/20 | 0.37 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.35 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9111447 | 0.91 | PPARA (0.47) | PPARAPPARGHDAC1HDAC6PPARD | |
| SCHEMBL8768939 | 0.87 | PPARA (0.45) | PPARAPPARGHDAC1HDAC6ABCB11 | |
| SCHEMBL8768894 | 0.83 | PPARA (0.50) | PPARAPPARGHDAC1HDAC6ABCB11 | |
| SCHEMBL8767770 | 0.80 | PPARA (0.47) | PPARAPPARGHDAC1HDAC6ABCB11 | |
| SCHEMBL8768867 | 0.78 | PPARA (0.48) | PPARAPPARGHDAC1HDAC6ABCB11 | |
| SCHEMBL8924428 | 0.75 | PPARA (0.42) | PPARAPPARGABCB11CYP1A2CYP3A4 | |
| SCHEMBL8768094 | 0.74 | PPARA (0.56) | PPARAPPARGABCB11CYP1A2CYP3A4 | |
| Hydrochloric Acid SCHEMBL11449524 | 0.72 | PPARA (0.58) | PPARAPPARGABCB11CYP1A2CYP3A4 | |
| SCHEMBL8769015 | 0.70 | PPARA (0.49) | PPARAPPARGHDAC1HDAC6ABCB11 | |
| SCHEMBL11449966 | 0.69 | PPARA (0.57) | PPARAPPARGABCB11CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0639178-B1 | ANTI-ATHEROSCLEROTIC ARYL COMPOUNDS | WELLCOME FOUND (GB) | 1997-09-03 | — | — | EP | disclosed |
| US-5658944-A | ANTICHOLESTEROL AGENTS | THE UNIVERSITY OF SOUTH CAROLINA (US) | 1997-08-19 | — | — | US | disclosed |