Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 9/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.42 |
| ▸ | PPARG | P37231 | 4/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.37 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.37 |
| ▸ | PPARD | Q03181 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | FAAH | O00519 | 1/20 | 0.34 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8768765 | 0.92 | PPARA (0.45) | PPARACYP1A2CYP3A4PPARGEPHX2 | |
| SCHEMBL8924425 | 0.81 | PPARA (0.44) | PPARACYP1A2ABCB11CYP3A4TSHR | |
| SCHEMBL8768939 | 0.80 | PPARA (0.45) | PPARACYP1A2ABCB11CYP3A4TSHR | |
| SCHEMBL8767770 | 0.76 | PPARA (0.47) | PPARACYP1A2ABCB11CYP3A4TSHR | |
| SCHEMBL8768894 | 0.75 | PPARA (0.50) | PPARACYP1A2ABCB11CYP3A4TSHR | |
| SCHEMBL8768870 | 0.75 | PPARA (0.44) | PPARACYP1A2ABCB11CYP3A4TSHR | |
| SCHEMBL8925468 | 0.73 | PPARA (0.47) | PPARACYP1A2ABCB11CYP3A4TSHR | |
| SCHEMBL8925426 | 0.73 | PPARA (0.45) | PPARATSHRPPARGPPARD | |
| SCHEMBL8768759 | 0.72 | PPARA (0.53) | PPARAPPARGPPARD | |
| SCHEMBL8768838 | 0.71 | PPARA (0.48) | PPARACYP1A2ABCB11CYP3A4TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5658944-A | ANTICHOLESTEROL AGENTS | THE UNIVERSITY OF SOUTH CAROLINA (US) | 1997-08-19 | — | — | US | disclosed |
| EP-0639178-A1 | ANTI-ATHEROSCLEROTIC ARYL COMPOUNDS. | WELLCOME FOUND (GB) | 1995-02-22 | — | — | EP | disclosed |
| WO-1992010468-A1 | ANTI-ATHEROSCLEROTIC ARYL COMPOUNDS | THE WELLCOME FOUNDATION LIMITED (GB) | 1992-06-25 | — | — | WO | disclosed |