SCHEMBL8768937

SCHEMBL8768937

CCCCCCCN(Cc1c(OC(C)(C)C(=O)OCC)cccc1-c1c(F)cc(F)cc1OC)C(N)=O

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PPARA Q07869 5/20 0.41
PPARG P37231 4/20 0.41
FBP1 P09467 2/20 0.37
SOAT1 P35610 1/20 0.34
CNR1 P21554 2/20 0.34
CNR2 P34972 2/20 0.34
ACHE P22303 1/20 0.33
PPARD Q03181 1/20 0.32
CYP1A2 P05177 2/20 0.32
CYP3A4 P08684 2/20 0.32
CYP2C19 P33261 2/20 0.32
CYP2D6 P10635 1/20 0.32
CTDSP1 Q9GZU7 1/20 0.31
TDP1 Q9NUW8 1/20 0.31
KDM4E B2RXH2 1/20 0.31
MEN1 O00255 1/20 0.31
ALDH1A1 P00352 1/20 0.31
MAPT P10636 1/20 0.31
CYP2C9 P11712 1/20 0.31
HPGD P15428 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8768928 0.74 SOAT1 (0.44) PPARAPPARGFBP1SOAT1ACHE
SCHEMBL7981278 0.67 FBP1 (0.60) PPARAPPARGFBP1CNR2CYP1A2
SCHEMBL1417534 0.67 FBP1 (0.62) PPARAPPARGFBP1CYP1A2CYP3A4
SCHEMBL8767912 0.65 SOAT1 (0.48) PPARAPPARGFBP1SOAT1ACHE
SCHEMBL8768990 0.65 PPARA (0.50) PPARAPPARGSOAT1PPARDCYP1A2
SCHEMBL12670823 0.65 FBP1 (0.56) PPARAPPARGFBP1CNR2CYP1A2
SCHEMBL8768903 0.65 PPARA (0.51) PPARAPPARGFBP1SOAT1PPARD
SCHEMBL8768601 0.64 PPARG (0.70) PPARAPPARGSOAT1PPARDMAPT
SCHEMBL8767877 0.63 HDAC6 (0.59) PPARAPPARGSOAT1PPARDCYP1A2
SCHEMBL8768641 0.62 PPARA (0.51) PPARAPPARGSOAT1CNR2PPARD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0639178-B1 ANTI-ATHEROSCLEROTIC ARYL COMPOUNDS WELLCOME FOUND (GB) 1997-09-03 EP disclosed
US-5658944-A ANTICHOLESTEROL AGENTS THE UNIVERSITY OF SOUTH CAROLINA (US) 1997-08-19 US disclosed
EP-0639178-A1 ANTI-ATHEROSCLEROTIC ARYL COMPOUNDS. WELLCOME FOUND (GB) 1995-02-22 EP disclosed
WO-1992010468-A1 ANTI-ATHEROSCLEROTIC ARYL COMPOUNDS THE WELLCOME FOUNDATION LIMITED (GB) 1992-06-25 WO disclosed