Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSB | P07858 | 6/20 | 0.64 |
| ▸ | CTSL | P07711 | 3/20 | 0.64 |
| ▸ | CTSS | P25774 | 3/20 | 0.64 |
| ▸ | MEN1 | O00255 | 2/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.62 |
| ▸ | LMNA | P02545 | 1/20 | 0.62 |
| ▸ | CASP3 | P42574 | 2/20 | 0.59 |
| ▸ | CTSK | P43235 | 5/20 | 0.56 |
| ▸ | CAPN1 | P07384 | 2/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | REN | P00797 | 1/20 | 0.54 |
| ▸ | MME | P08473 | 1/20 | 0.53 |
| ▸ | ECE1 | P42892 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8770292 | 0.89 | CTSB (0.61) | CTSBCTSLCTSSMEN1KMT2A | |
| SCHEMBL8770094 | 0.88 | CTSB (0.60) | CTSBCTSLCTSSMEN1KMT2A | |
| SCHEMBL29861422 | 0.86 | CTSB (0.61) | CTSBCTSLCTSSMEN1KMT2A | |
| SCHEMBL13938046 | 0.86 | CTSB (0.58) | CTSBCTSLCTSSMEN1KMT2A | |
| SCHEMBL13938041 | 0.86 | CTSB (0.58) | CTSBCTSLCTSSMEN1KMT2A | |
| SCHEMBL13296495 | 0.85 | CAPN1 (0.63) | CTSBCTSLCTSSCTSKCAPN1 | |
| SCHEMBL13937912 | 0.85 | CTSB (0.57) | CTSBCTSLCTSSMEN1KMT2A | |
| SCHEMBL13937914 | 0.84 | CTSK (0.60) | CTSBCTSLCTSSMEN1KMT2A | |
| SCHEMBL13683312 | 0.84 | CTSK (0.60) | CTSBCTSLCTSSMEN1KMT2A | |
| SCHEMBL7049933 | 0.83 | CTSB (0.72) | CTSBCTSLCTSSMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0793673-A1 | ALPHA-KETOAMIDE DERIVATIVES AS CATHEPSIN L INHIBITOR | Takeda Chemical Industries, Ltd. (JP) | 1997-09-10 | — | — | EP | disclosed |
| WO-1996016079-A2 | ALPHA-KETOAMIDE DERIVATIVES AS CATHEPSIN L INHIBITOR | TAKEDA CHEMICAL INDUSTRIES, LTD (JP) | 1996-05-30 | — | — | WO | disclosed |