Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | ITGB1 | P05556 | 3/20 | 0.36 |
| ▸ | ITGA4 | P13612 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 6/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 4/20 | 0.34 |
| ▸ | RAB9A | P51151 | 4/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.34 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.34 |
| ▸ | NAMPT | P43490 | 1/20 | 0.33 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.33 |
| ▸ | ITGAV | P06756 | 1/20 | 0.33 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.33 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8770331 | 0.91 | F2 (0.39) | ALDH1A1ITGB1ITGA4MAPTHSD17B10 | |
| SCHEMBL8770391 | 0.86 | CYP19A1 (0.38) | ALDH1A1ITGB1ITGA4MAPTNPC1 | |
| SCHEMBL8770215 | 0.86 | NPC1 (0.43) | ALDH1A1GAAITGB1ITGA4MAPT | |
| SCHEMBL8770257 | 0.81 | NPC1 (0.44) | ALDH1A1GAAMAPTNPC1RAB9A | |
| SCHEMBL8770327 | 0.77 | NPC1 (0.43) | ITGB1ITGA4NPC1RAB9AS1PR1 | |
| SCHEMBL8770298 | 0.74 | MAPT (0.39) | ALDH1A1GAAMAPTNPC1RAB9A | |
| SCHEMBL8770248 | 0.72 | NPC1 (0.42) | ITGB1ITGA4NPC1RAB9AMEN1 | |
| SCHEMBL8770417 | 0.72 | NPC1 (0.44) | NPC1RAB9ASMN1; SMN2TP53ITGB3 | |
| SCHEMBL8770289 | 0.71 | P4HTM (0.45) | ALDH1A1GAAMAPTNPC1RAB9A | |
| SCHEMBL8770183 | 0.71 | NPC1 (0.51) | ALDH1A1MAPTHSD17B10NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0632019-B1 | Acylureas | ZENECA LTD (GB) | 1997-09-24 | — | — | EP | disclosed |
| US-5576334-A | ANTICOAGULANTS | ZENECA LIMITED (GB) | 1996-11-19 | — | — | US | disclosed |
| EP-0632019-A1 | Acylureas | ZENECA LIMITED (GB) | 1995-01-04 | — | — | EP | disclosed |