Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | TMPRSS15 | P98073 | 7/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 6/20 | 0.39 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.38 |
| ▸ | PRSS1 | P07477 | 5/20 | 0.38 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.38 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.38 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.37 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.37 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.37 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.37 |
| ▸ | F2 | P00734 | 1/20 | 0.37 |
| ▸ | TMPRSS6 | Q8IU80 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8770215 | 0.90 | NPC1 (0.43) | NPC1RAB9AEPHX2FFAR1MCHR1 | |
| SCHEMBL8770331 | 0.86 | F2 (0.39) | NPC1RAB9APRSS1ITGB1ITGA4 | |
| SCHEMBL8770248 | 0.86 | NPC1 (0.42) | NPC1RAB9AEPHX2FFAR1MCHR1 | |
| SCHEMBL8770417 | 0.84 | NPC1 (0.44) | NPC1RAB9APRSS1F2TMPRSS6 | |
| SCHEMBL8770309 | 0.77 | ALDH1A1 (0.37) | NPC1RAB9AITGB1ITGA4S1PR1 | |
| SCHEMBL8770192 | 0.76 | ITGB3 (0.51) | PRSS1ITGB1F2TMPRSS6 | |
| SCHEMBL8770268 | 0.76 | MAPT (0.39) | NPC1RAB9AMCHR1F2 | |
| SCHEMBL8770257 | 0.74 | NPC1 (0.44) | NPC1RAB9A | |
| SCHEMBL8770576 | 0.73 | P4HTM (0.45) | NPC1RAB9AF2 | |
| SCHEMBL8770638 | 0.73 | NPC1 (0.51) | NPC1RAB9APRSS1F2TMPRSS6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0632019-B1 | Acylureas | ZENECA LTD (GB) | 1997-09-24 | — | — | EP | disclosed |
| US-5576334-A | ANTICOAGULANTS | ZENECA LIMITED (GB) | 1996-11-19 | — | — | US | disclosed |
| EP-0632019-A1 | Acylureas | ZENECA LIMITED (GB) | 1995-01-04 | — | — | EP | disclosed |