Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 4/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.39 |
| ▸ | MLYCD | O95822 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.38 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.37 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.37 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.37 |
| ▸ | AR | P10275 | 2/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8770391 | 0.86 | CYP19A1 (0.38) | NPC1RAB9AMEN1KMT2ACYP19A1 | |
| SCHEMBL8770215 | 0.86 | NPC1 (0.43) | NPC1RAB9AMEN1KMT2AFFAR1 | |
| SCHEMBL8770327 | 0.86 | NPC1 (0.43) | NPC1RAB9AFFAR1EPHX2MCHR1 | |
| SCHEMBL8770581 | 0.85 | MAPT (0.48) | NPC1RAB9AMEN1KMT2AMLYCD | |
| SCHEMBL8770325 | 0.76 | MAPT (0.39) | NPC1RAB9AMEN1KMT2AMCHR1 | |
| SCHEMBL8770323 | 0.74 | KMT2A (0.52) | NPC1RAB9AMEN1KMT2AMLYCD | |
| SCHEMBL8770181 | 0.74 | KMT2A (0.52) | NPC1RAB9AMEN1KMT2AMLYCD | |
| SCHEMBL8770365 | 0.74 | PTPN1 (0.42) | NPC1RAB9AMEN1KMT2AAR | |
| SCHEMBL8770331 | 0.72 | F2 (0.39) | NPC1RAB9AMEN1KMT2AITGB1 | |
| SCHEMBL8770309 | 0.72 | ALDH1A1 (0.37) | NPC1RAB9AMEN1KMT2AITGB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0632019-B1 | Acylureas | ZENECA LTD (GB) | 1997-09-24 | — | — | EP | disclosed |
| US-5576334-A | ANTICOAGULANTS | ZENECA LIMITED (GB) | 1996-11-19 | — | — | US | disclosed |
| EP-0632019-A1 | Acylureas | ZENECA LIMITED (GB) | 1995-01-04 | — | — | EP | disclosed |