Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 4/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
| ▸ | PPARD | Q03181 | 1/20 | 0.34 |
| ▸ | PPARA | Q07869 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8770200 | 0.75 | CHRM3 (0.40) | CYP2C9CYP1A2CYP2C19CYP3A4MRGPRX4 | |
| SCHEMBL8770550 | 0.74 | LMNA (0.47) | CYP1A2CYP2C19HIF1AALDH1A1KDM4E | |
| SCHEMBL9621461 | 0.72 | CYP2C9 (0.53) | CYP2C9CYP1A2CYP2C19CYP3A4HIF1A | |
| SCHEMBL912792 | 0.71 | CYP2C9 (0.67) | CYP2C9CYP1A2CYP2C19CYP3A4HIF1A | |
| SCHEMBL10816083 | 0.70 | HTR1B (0.42) | CYP2C9CYP1A2CYP2C19ALDH1A1KDM4E | |
| Phosphine SCHEMBL11171774 | 0.69 | CYP2C9 (0.64) | CYP2C9CYP1A2CYP2C19CYP3A4HIF1A | |
| SCHEMBL11091669 | 0.69 | KDM4E (0.52) | CYP2C9CYP1A2CYP2C19ALDH1A1KDM4E | |
| SCHEMBL11090671 | 0.67 | KDM4E (0.50) | CYP2C9CYP1A2CYP2C19CYP3A4ALDH1A1 | |
| SCHEMBL5726192 | 0.66 | CHRM4 (0.55) | KDM4EMAPK1CYP2D6LMNAHTR2A | |
| SCHEMBL27977085 | 0.66 | MEN1 (0.45) | CYP2C9CYP1A2CYP2C19ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5693674-A | Method of using triaryl-ethylene derivatives in the treatment and prevention of osteoporosis | HOECHST MARION ROUSSEL, INC. (US) | 1997-12-02 | — | — | US | disclosed |
| US-5691384-A | Method of using triaryl-ethylene derivatives in the treatment and prevention of osteoporosis | HOECHST MARION ROUSSEL, INC. (US) | 1997-11-25 | — | — | US | disclosed |
| EP-0794771-A1 | METHOD OF USING TRIARYL-ETHYLENE DERIVATIVES IN THE TREATMENT AND PREVENTION OF OSTEOPOROSIS | HOECHST MARION ROUSSEL, INC. (US) | 1997-09-17 | — | — | EP | disclosed |
| WO-1996016646-A1 | METHOD OF USING TRIARYL-ETHYLENE DERIVATIVES IN THE TREATMENT AND PREVENTION OF OSTEOPOROSIS | HOECHST MARION ROUSSEL, INC. (US) | 1996-06-06 | — | — | WO | disclosed |