Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 6/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | JAK2 | O60674 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | KCNA3 | P22001 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11091669 | 0.97 | KDM4E (0.52) | KDM4EL3MBTL1TDP1NPC1POLB | |
| SCHEMBL11097405 | 0.90 | KDM4E (0.54) | KDM4EL3MBTL1TDP1NPC1POLB | |
| SCHEMBL9547466 | 0.89 | L3MBTL1 (0.65) | L3MBTL1TDP1NPC1MAPTLMNA | |
| SCHEMBL28809812 | 0.87 | L3MBTL1 (0.52) | KDM4EL3MBTL1TDP1NPC1POLB | |
| SCHEMBL5659890 | 0.87 | L3MBTL1 (0.67) | L3MBTL1TDP1NPC1MAPTLMNA | |
| SCHEMBL3472110 | 0.85 | NPC1 (0.42) | KDM4EL3MBTL1TDP1NPC1POLB | |
| SCHEMBL20530589 | 0.85 | ALDH1A1 (0.58) | KDM4EL3MBTL1TDP1NPC1MAPT | |
| SCHEMBL20530525 | 0.85 | ALDH1A1 (0.58) | KDM4EL3MBTL1TDP1NPC1MAPT | |
| SCHEMBL9150153 | 0.85 | GAA (0.67) | L3MBTL1NPC1POLBPTK2BMAPT | |
| SCHEMBL6848695 | 0.84 | KDM4E (0.54) | KDM4EL3MBTL1TDP1NPC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0032063-B1 | NOVEL SUBSTITUTED ARYLENE COMPOUNDS AND PROCESSES FOR THEIR PRODUCTION | WARNER-LAMBERT COMPANY (US) | 1984-03-14 | — | — | EP | disclosed |
| US-4351950-A | Anti-arteriosclerotic agents | WARNER-LAMBERT COMPANY (US) | 1982-09-28 | — | — | US | disclosed |
| EP-0032063-A2 | Novel substituted arylene compounds and processes for their production | WARNER-LAMBERT COMPANY (US) | 1981-07-15 | — | — | EP | disclosed |