Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 17/20 | 0.39 |
| ▸ | RXRB | P28702 | 9/20 | 0.39 |
| ▸ | RXRG | P48443 | 9/20 | 0.39 |
| ▸ | RARB | P10826 | 5/20 | 0.37 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP26B1 | Q9NR63 | 1/20 | 0.35 |
| ▸ | RARG | P13631 | 4/20 | 0.35 |
| ▸ | HNF4A | P41235 | 2/20 | 0.35 |
| ▸ | RARA | P10276 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8981892 | 0.94 | RXRA (0.39) | RXRARXRBRXRGRARBCYP26A1 | |
| SCHEMBL8771918 | 0.83 | RXRA (0.47) | RXRARXRBRXRGRARBCYP26A1 | |
| SCHEMBL8771668 | 0.81 | RXRA (0.48) | RXRARXRBRXRGRARBCYP26A1 | |
| SCHEMBL8771954 | 0.80 | RXRA (0.44) | RXRARXRBRXRGRARBCYP26A1 | |
| SCHEMBL6292577 | 0.71 | RARB (0.51) | RXRARXRBRXRGRARBCYP26A1 | |
| SCHEMBL8771700 | 0.68 | RXRA (0.67) | RXRARXRBRXRGRARBCYP26A1 | |
| SCHEMBL6236585 | 0.67 | RARB (0.67) | RXRARXRBRXRGRARBCYP26A1 | |
| SCHEMBL6759491 | 0.67 | RARB (0.67) | RXRARXRBRXRGRARBCYP26A1 | |
| SCHEMBL7640552 | 0.67 | RARB (0.67) | RARBCYP26A1CYP3A4RARGRARA | |
| SCHEMBL6236579 | 0.67 | RARB (0.67) | RXRARXRBRXRGRARBCYP26A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0661259-B1 | Substituted (5,6)-dihydronaphthalenyl compounds having retinoid-like activity | BRISTOL MYERS SQUIBB CO (US) | 1997-10-08 | — | — | EP | disclosed |
| US-5648385-A | TREATING RHEUMATOID ARTHRITIS | BRISTOL-MYERS SQUIBB CO. (US) | 1997-07-15 | — | — | US | disclosed |
| EP-0661259-A1 | Substituted (5,6)-dihydronaphthalenyl compounds having retinoid-like activity | BRISTOL-MYERS SQUIBB COMPANY (US) | 1995-07-05 | — | — | EP | disclosed |