Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARA | P10276 | 18/20 | 0.70 |
| ▸ | RARB | P10826 | 18/20 | 0.70 |
| ▸ | RARG | P13631 | 17/20 | 0.70 |
| ▸ | RXRA | P19793 | 1/20 | 0.70 |
| ▸ | NR2E1 | Q9Y466 | 1/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5329024 | 0.88 | RARB (0.55) | RARARARBRARGRXRANR2E1 | |
| SCHEMBL6755033 | 0.82 | RARA (1.00) | RARARARBRARGRXRANR2E1 | |
| SCHEMBL29613352 | 0.82 | RARA (1.00) | RARARARBRARGRXRANR2E1 | |
| SCHEMBL6755036 | 0.82 | RARA (1.00) | RARARARBRARGRXRANR2E1 | |
| SCHEMBL14075536 | 0.80 | RARB (0.53) | RARARARBRARGRXRANR2E1 | |
| SCHEMBL6261635 | 0.80 | RARB (0.57) | RARARARBRARGRXRANR2E1 | |
| SCHEMBL6453060 | 0.79 | RXRA (0.48) | RARARARBRARGRXRANR2E1 | |
| SCHEMBL8026108 | 0.79 | RARA (0.80) | RARARARBRARGRXRANR2E1 | |
| SCHEMBL8771694 | 0.78 | RARB (0.56) | RARARARBRARGRXRANR2E1 | |
| SCHEMBL8771774 | 0.78 | RARB (0.60) | RARARARBRARGRXRANR2E1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0661259-B1 | Substituted (5,6)-dihydronaphthalenyl compounds having retinoid-like activity | BRISTOL MYERS SQUIBB CO (US) | 1997-10-08 | — | — | EP | disclosed |
| US-5648385-A | TREATING RHEUMATOID ARTHRITIS | BRISTOL-MYERS SQUIBB CO. (US) | 1997-07-15 | — | — | US | disclosed |
| US-5618839-A | Retinoid-like compounds | BRISTOL-MYERS SQUIBB COMPANY (US) | 1997-04-08 | — | — | US | disclosed |
| EP-0661259-A1 | Substituted (5,6)-dihydronaphthalenyl compounds having retinoid-like activity | BRISTOL-MYERS SQUIBB COMPANY (US) | 1995-07-05 | — | — | EP | disclosed |