Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | AR | P10275 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.46 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.46 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.46 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.46 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.46 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.46 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.46 |
| ▸ | CYP26A1 | O43174 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL803657 | 0.81 | PDK2 (0.47) | SMN1; SMN2MAPTLMNANPSR1MEN1 | |
| SCHEMBL8771839 | 0.76 | PTPN1 (0.52) | RAB9AMAPTLMNANPSR1NPC1 | |
| SCHEMBL8771845 | 0.76 | PTPN1 (0.52) | RAB9AMAPTLMNANPSR1NPC1 | |
| SCHEMBL10236929 | 0.75 | RAB9A (0.82) | RAB9ASMN1; SMN2MAPTLMNANPC1 | |
| SCHEMBL11350421 | 0.75 | RAB9A (0.82) | RAB9ASMN1; SMN2MAPTLMNANPC1 | |
| SCHEMBL20798188 | 0.75 | MAOA (0.59) | RAB9ASMN1; SMN2MAPTNPC1MEN1 | |
| SCHEMBL8771810 | 0.74 | KMT2A (0.48) | RAB9ASMN1; SMN2MAPTLMNANPC1 | |
| SCHEMBL5090826 | 0.74 | MAPT (0.62) | RAB9ASMN1; SMN2MAPTLMNANPC1 | |
| SCHEMBL22500122 | 0.74 | MAOA (0.70) | RAB9ASMN1; SMN2MAPTNPC1MAOB | |
| SCHEMBL3729907 | 0.72 | NPC1 (0.75) | RAB9ASMN1; SMN2MAPTLMNANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0661259-B1 | Substituted (5,6)-dihydronaphthalenyl compounds having retinoid-like activity | BRISTOL MYERS SQUIBB CO (US) | 1997-10-08 | — | — | EP | disclosed |
| US-5648385-A | TREATING RHEUMATOID ARTHRITIS | BRISTOL-MYERS SQUIBB CO. (US) | 1997-07-15 | — | — | US | disclosed |
| US-5618839-A | Retinoid-like compounds | BRISTOL-MYERS SQUIBB COMPANY (US) | 1997-04-08 | — | — | US | disclosed |
| EP-0661259-A1 | Substituted (5,6)-dihydronaphthalenyl compounds having retinoid-like activity | BRISTOL-MYERS SQUIBB COMPANY (US) | 1995-07-05 | — | — | EP | disclosed |