Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 13/20 | 0.55 |
| ▸ | RXRA | P19793 | 13/20 | 0.55 |
| ▸ | RARG | P13631 | 12/20 | 0.55 |
| ▸ | RXRB | P28702 | 8/20 | 0.55 |
| ▸ | RXRG | P48443 | 6/20 | 0.55 |
| ▸ | RARA | P10276 | 12/20 | 0.54 |
| ▸ | CYP26A1 | O43174 | 4/20 | 0.54 |
| ▸ | CYP26B1 | Q9NR63 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | GMNN | O75496 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL846110 | 0.80 | RARB (0.81) | RARBRXRARARGRXRBRXRG | |
| SCHEMBL29827631 | 0.80 | RARB (0.81) | RARBRXRARARGRXRBRXRG | |
| SCHEMBL8771841 | 0.80 | RARB (0.58) | RARBRXRARARGRXRBRXRG | |
| SCHEMBL8981549 | 0.79 | RARB (0.51) | RARBRXRARARGRXRBRXRG | |
| Hydrochloric Acid SCHEMBL9120757 | 0.78 | RARB (0.78) | RARBRXRARARGRXRBRXRG | |
| SCHEMBL8771681 | 0.78 | RARB (0.53) | RARBRXRARARGRXRBRXRG | |
| SCHEMBL8771781 | 0.77 | RARB (0.67) | RARBRXRARARGRXRBRXRG | |
| Hydrazine SCHEMBL9430381 | 0.77 | RARB (0.76) | RARBRXRARARGRXRBRXRG | |
| SCHEMBL8669998 | 0.75 | RARB (0.54) | RARBRXRARARGRXRBRXRG | |
| SCHEMBL8771721 | 0.72 | RXRA (0.60) | RARBRXRARARGRXRBRXRG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0661259-B1 | Substituted (5,6)-dihydronaphthalenyl compounds having retinoid-like activity | BRISTOL MYERS SQUIBB CO (US) | 1997-10-08 | — | — | EP | disclosed |
| US-5648385-A | TREATING RHEUMATOID ARTHRITIS | BRISTOL-MYERS SQUIBB CO. (US) | 1997-07-15 | — | — | US | disclosed |
| US-5618839-A | Retinoid-like compounds | BRISTOL-MYERS SQUIBB COMPANY (US) | 1997-04-08 | — | — | US | disclosed |
| EP-0661259-A1 | Substituted (5,6)-dihydronaphthalenyl compounds having retinoid-like activity | BRISTOL-MYERS SQUIBB COMPANY (US) | 1995-07-05 | — | — | EP | disclosed |