Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARA | P10276 | 3/20 | 0.55 |
| ▸ | RARB | P10826 | 2/20 | 0.55 |
| ▸ | RARG | P13631 | 2/20 | 0.55 |
| ▸ | RXRA | P19793 | 1/20 | 0.55 |
| ▸ | NR2E1 | Q9Y466 | 1/20 | 0.55 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.49 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | CDC25B | P30305 | 2/20 | 0.43 |
| ▸ | PTPRC | P08575 | 1/20 | 0.43 |
| ▸ | PTPRF | P10586 | 1/20 | 0.43 |
| ▸ | VDR | P11473 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 4/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8771880 | 1.00 | RARA (0.55) | RARARARBRARGRXRANR2E1 | |
| SCHEMBL4653407 | 0.88 | RARB (0.69) | RARARARBRARGRXRANR2E1 | |
| SCHEMBL4653408 | 0.88 | RARB (0.69) | RARARARBRARGRXRANR2E1 | |
| SCHEMBL8771689 | 0.88 | PDK2 (0.49) | RARARARBRARGRXRANR2E1 | |
| SCHEMBL8026108 | 0.83 | RARA (0.80) | RARARARBRARGRXRANR2E1 | |
| SCHEMBL8771636 | 0.82 | RARA (0.58) | RARARARBRARGPTPN1NPC1 | |
| SCHEMBL8771705 | 0.82 | PTPN1 (0.55) | RARARARBRARGPTPN1NPC1 | |
| SCHEMBL8771810 | 0.79 | KMT2A (0.48) | NPC1RAB9ALMNAMAPTALDH1A1 | |
| SCHEMBL17275573 | 0.77 | RARB (0.50) | RARARARBRARGRXRANR2E1 | |
| SCHEMBL7532838 | 0.77 | EGFR (0.60) | PTPN1EGFRNPC1RAB9ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0661259-B1 | Substituted (5,6)-dihydronaphthalenyl compounds having retinoid-like activity | BRISTOL MYERS SQUIBB CO (US) | 1997-10-08 | — | — | EP | disclosed |
| US-5648385-A | TREATING RHEUMATOID ARTHRITIS | BRISTOL-MYERS SQUIBB CO. (US) | 1997-07-15 | — | — | US | disclosed |
| US-5618839-A | Retinoid-like compounds | BRISTOL-MYERS SQUIBB COMPANY (US) | 1997-04-08 | — | — | US | disclosed |
| CN-1144217-A | Retinoid-like compounds | BRISTOL MYERS SQUIBB CO (US) | 1997-03-05 | — | — | CN | disclosed |
| EP-0661259-A1 | Substituted (5,6)-dihydronaphthalenyl compounds having retinoid-like activity | BRISTOL-MYERS SQUIBB COMPANY (US) | 1995-07-05 | — | — | EP | disclosed |