Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 4/20 | 0.50 |
| ▸ | RARB | P10826 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | RARA | P10276 | 2/20 | 0.50 |
| ▸ | RARG | P13631 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | PKM | P14618 | 2/20 | 0.47 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8771636 | 0.93 | RARA (0.58) | PTPN1KMT2ACTDSP1RAB9ARARB | |
| SCHEMBL8771889 | 0.90 | RARA (0.61) | KMT2ARAB9ARARBRARARARG | |
| SCHEMBL8771689 | 0.86 | PDK2 (0.49) | PTPN1KMT2ARAB9ARARBRARA | |
| SCHEMBL27462421 | 0.84 | RARA (0.72) | PTPN1KMT2ACTDSP1RAB9ARARB | |
| SCHEMBL4653413 | 0.83 | RARA (0.71) | KMT2ARARBKDM4ERARARARG | |
| SCHEMBL8771880 | 0.82 | RARA (0.55) | PTPN1KMT2ARAB9ARARBRARA | |
| SCHEMBL8771890 | 0.82 | RARA (0.55) | PTPN1KMT2ARAB9ARARBRARA | |
| SCHEMBL8771810 | 0.78 | KMT2A (0.48) | KMT2ARAB9ASMN1; SMN2KDM4EMEN1 | |
| SCHEMBL17275573 | 0.75 | RARB (0.50) | KMT2ARARBRARARARGALDH1A1 | |
| SCHEMBL22223650 | 0.75 | PTPN1 (0.94) | PTPN1KMT2ARAB9ASMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0661259-B1 | Substituted (5,6)-dihydronaphthalenyl compounds having retinoid-like activity | BRISTOL MYERS SQUIBB CO (US) | 1997-10-08 | — | — | EP | disclosed |
| US-5648385-A | TREATING RHEUMATOID ARTHRITIS | BRISTOL-MYERS SQUIBB CO. (US) | 1997-07-15 | — | — | US | disclosed |
| US-5618839-A | Retinoid-like compounds | BRISTOL-MYERS SQUIBB COMPANY (US) | 1997-04-08 | — | — | US | disclosed |
| CN-1144217-A | Retinoid-like compounds | BRISTOL MYERS SQUIBB CO (US) | 1997-03-05 | — | — | CN | disclosed |
| EP-0661259-A1 | Substituted (5,6)-dihydronaphthalenyl compounds having retinoid-like activity | BRISTOL-MYERS SQUIBB COMPANY (US) | 1995-07-05 | — | — | EP | disclosed |