Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAAT3 | P53816 | 1/20 | 0.46 |
| ▸ | PLAAT5 | Q96KN8 | 1/20 | 0.46 |
| ▸ | PLAAT2 | Q9NWW9 | 1/20 | 0.46 |
| ▸ | PLAAT4 | Q9UL19 | 1/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | ASAH1 | Q13510 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27495131 | 0.88 | KMT2A (0.45) | POLBALDH1A1 | |
| SCHEMBL8438262 | 0.88 | PLAAT3 (0.47) | PLAAT3PLAAT5PLAAT2PLAAT4HRH3 | |
| SCHEMBL20971533 | 0.88 | PLAAT3 (0.47) | PLAAT3PLAAT5PLAAT2PLAAT4HRH3 | |
| SCHEMBL27479451 | 0.88 | PLAAT3 (0.47) | PLAAT3PLAAT5PLAAT2PLAAT4HRH3 | |
| SCHEMBL8442091 | 0.88 | PLAAT3 (0.47) | PLAAT3PLAAT5PLAAT2PLAAT4HRH3 | |
| SCHEMBL8522255 | 0.88 | PLAAT3 (0.47) | PLAAT3PLAAT5PLAAT2PLAAT4HRH3 | |
| SCHEMBL8439673 | 0.88 | PLAAT3 (0.47) | PLAAT3PLAAT5PLAAT2PLAAT4HRH3 | |
| SCHEMBL20971523 | 0.88 | PLAAT3 (0.47) | PLAAT3PLAAT5PLAAT2PLAAT4HRH3 | |
| SCHEMBL8772526 | 0.88 | PLAAT3 (0.47) | PLAAT3PLAAT5PLAAT2PLAAT4HRH3 | |
| SCHEMBL8438266 | 0.88 | PLAAT3 (0.47) | PLAAT3PLAAT5PLAAT2PLAAT4HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0799200-A1 | SUBSTITUTED AZETIDIN-2-ONES FOR TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1997-10-08 | — | — | EP | claimed |
| EP-0799200-A1 | SUBSTITUTED AZETIDIN-2-ONES FOR TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1997-10-08 | — | — | EP | disclosed |
| WO-1996019451-A1 | SUBSTITUTED AZETIDIN-2-ONES FOR TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1996-06-27 | — | — | WO | disclosed |