Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | BCHE | P06276 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8439022 | 0.93 | MAPT (0.42) | KMT2APOLBALDH1A1MAPTGAA | |
| SCHEMBL8442110 | 0.89 | ALDH1A1 (0.43) | KMT2APOLBALDH1A1GAATRPV1 | |
| SCHEMBL27495125 | 0.89 | TRPV1 (0.48) | KMT2AALDH1A1GAATRPV1TSHR | |
| SCHEMBL27515042 | 0.89 | TRPV1 (0.48) | KMT2AALDH1A1GAATRPV1TSHR | |
| SCHEMBL27493521 | 0.89 | TRPV1 (0.48) | KMT2AALDH1A1GAATRPV1TSHR | |
| SCHEMBL8772503 | 0.89 | TRPV1 (0.48) | KMT2AALDH1A1GAATRPV1TSHR | |
| SCHEMBL27515045 | 0.89 | TRPV1 (0.48) | KMT2AALDH1A1GAATRPV1TSHR | |
| SCHEMBL8438732 | 0.89 | TRPV1 (0.48) | KMT2AALDH1A1GAATRPV1TSHR | |
| SCHEMBL8442084 | 0.89 | TRPV1 (0.48) | KMT2AALDH1A1GAATRPV1TSHR | |
| SCHEMBL8772522 | 0.88 | TRPV1 (0.46) | KMT2AALDH1A1GAATRPV1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0799200-A1 | SUBSTITUTED AZETIDIN-2-ONES FOR TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1997-10-08 | — | — | EP | disclosed |
| WO-1996019451-A1 | SUBSTITUTED AZETIDIN-2-ONES FOR TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1996-06-27 | — | — | WO | disclosed |