Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.57 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.49 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | TERT | O14746 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | BLM | P54132 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | FABP4 | P15090 | 2/20 | 0.45 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.45 |
| ▸ | PPARG | P37231 | 2/20 | 0.45 |
| ▸ | PPARD | Q03181 | 2/20 | 0.45 |
| ▸ | PPARA | Q07869 | 2/20 | 0.45 |
| ▸ | GMNN | O75496 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28487707 | 0.92 | HRH3 (0.62) | HRH3EPHX2KMT2AMEN1TERT | |
| SCHEMBL428924 | 0.88 | HRH3 (0.58) | HRH3KMT2AMEN1MAPTBLM | |
| SCHEMBL432074 | 0.83 | HSP90AA1 (0.50) | HRH3KMT2AMEN1POLBFAAH | |
| Hydrochloric Acid SCHEMBL116063 | 0.81 | HSP90AA1 (0.48) | HRH3KMT2AMEN1POLBFAAH | |
| SCHEMBL11755295 | 0.77 | HRH3 (0.58) | HRH3EPHX2KMT2AMEN1TERT | |
| Bromide SCHEMBL2169637 | 0.77 | HRH3 (0.69) | HRH3EPHX2KMT2AMEN1TERT | |
| SCHEMBL28441056 | 0.76 | HRH3 (0.68) | HRH3EPHX2KMT2AMEN1TERT | |
| SCHEMBL11899543 | 0.76 | HRH3 (0.68) | HRH3EPHX2KMT2AMEN1TERT | |
| SCHEMBL11260057 | 0.75 | HRH3 (0.71) | HRH3EPHX2KMT2AMEN1TERT | |
| SCHEMBL11260061 | 0.75 | HRH3 (0.71) | HRH3EPHX2KMT2AMEN1TERT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0475191-B1 | Method for producing silver halide photographic emulsion | FUJI PHOTO FILM CO LTD (JP) | 1997-10-29 | — | — | EP | disclosed |
| US-5206134-A | Adding simultaneously silver nitrate and metal iodide solutions or adding fine particles of silver iodide and/or silver iodobromide, producing grains with low surface iodide content | FUJI PHOTO FILM CO., LTD. (JP) | 1993-04-27 | — | — | US | disclosed |
| EP-0475191-A2 | Method for producing silver halide photographic emulsion | FUJI PHOTO FILM CO., LTD. (JP) | 1992-03-18 | — | — | EP | disclosed |