⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10361273 | 1.00 | — | — | |
| SCHEMBL8376353 | 0.79 | — | — | |
| SCHEMBL11134388 | 0.76 | — | — | |
| SCHEMBL3401100 | 0.76 | — | — | |
| SCHEMBL8884033 | 0.69 | — | — | |
| SCHEMBL436317 | 0.66 | — | — | |
| SCHEMBL3857575 | 0.61 | — | — | |
| Potassium Ion SCHEMBL2792103 | 0.61 | — | — | |
| SCHEMBL22418788 | 0.61 | — | — | |
| SCHEMBL20942946 | 0.61 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0190534-B1 | PROCESS FOR THE PREPARATION OF ERGOLINE DERIVATIVES | SCHERING AKTIENGESELLSCHAFT (DE) | 1988-11-30 | — | — | EP | claimed |
| EP-0190534-A1 | Process for the preparation of ergoline derivatives | SCHERING AKTIENGESELLSCHAFT (DE) | 1986-08-13 | — | — | EP | claimed |
| EP-4036098-B1 | SYNTHESIS OF REVERSIBLE NUCLEOTIDE TERMINATORS BY IN-SITU THIO-ALKYL GROUP TRANSFER FOR USE IN DNA SEQUENCING BY SYNTHESIS | MILTENYI BIOTEC BV & CO KG (DE) | 2026-01-28 | — | — | EP | disclosed |
| EP-4476234-A1 | USE OF 3'-OXYMETHYLENE ALKYL DISULFIDE PROTECTED NUCLEOTIDES FOR ENZYMATIC DNA AND RNA SYNTHESIS | Miltenyi Biotec B.V. & Co. KG (DE) | 2024-12-18 | — | — | EP | disclosed |
| US-11767339-B2 | Synthesis of reversible nucleotide terminators by in-situ thio-alkyl group transfer for use in DNA sequencing by synthesis | Miltenyi Biotech B.V. & Co. KG (DE) | 2023-09-26 | — | — | US | disclosed |
| WO-2023152269-A1 | USE OF 3'-OXYMETHYLENE ALKYL DISULFIDE PROTECTED NUCLEOTIDES FOR ENZYMATIC DNA AND RNA SYNTHESIS | Miltenyi Biotec B.V. & Co. KG (DE) | 2023-08-17 | — | — | WO | disclosed |
| US-20230014428-A1 | SYNTHESIS OF REVERSIBLE NUCLEOTIDE TERMINATORS BY IN-SITU THIO-ALKYL GROUP TRANSFER FOR USE IN DNA SEQUENCING BY SYNTHESIS | Miltenyi Biotec B.V. & Co. KG (DE) | 2023-01-19 | — | — | US | disclosed |
| EP-4036098-A1 | SYNTHESIS OF REVERSIBLE NUCLEOTIDE TERMINATORS BY IN-SITU THIO-ALKYL GROUP TRANSFER FOR USE IN DNA SEQUENCING BY SYNTHESIS | Miltenyi Biotec B.V. & Co. KG (DE) | 2022-08-03 | — | — | EP | disclosed |
| EP-0515646-B1 | ANION EXCHANGER | PHARMACIA BIOTECH AB (SE) | 1997-09-03 | — | — | EP | disclosed |
| US-5466368-A | Quaternary ammonium or sulfonium groups, chromatographic separation of proteins | PHARMACIA LKB BIOTECHNOLOGY AB (SE) | 1995-11-14 | — | — | US | disclosed |
| EP-0160842-B1 | 2-Substituted ergoline derivatives, processes for their preparation, and their use as medicaments | SCHERING AG (DE) | 1994-06-22 | — | — | EP | disclosed |
| EP-0515646-A1 | ANION EXCHANGER. | PHARMACIA LKB BIOTECH (SE) | 1992-12-02 | — | — | EP | disclosed |
| EP-0217736-B1 | 1,2-DISUBSTITUTED ERGOLINE DERIVATIVES | SCHERING AKTIENGESELLSCHAFT (DE) | 1992-04-15 | — | — | EP | disclosed |
| US-4968801-A | Process for the production ergoline derivatives | SCHERING AKTIENGESELLSCHAFT (DE) | 1990-11-06 | — | — | US | disclosed |
| US-4874768-A | ANTIDEPRESSANTS, TREATMENT OF SCHIZOPHRENIA | SCHERING AKTIENGESELLSCHAFT (DE) | 1989-10-17 | — | — | US | disclosed |
| EP-0190534-B1 | PROCESS FOR THE PREPARATION OF ERGOLINE DERIVATIVES | SCHERING AKTIENGESELLSCHAFT (DE) | 1988-11-30 | — | — | EP | disclosed |
| EP-0217736-A2 | 1,2-Disubstituted ergoline derivatives | SCHERING AKTIENGESELLSCHAFT (DE) | 1987-04-08 | — | — | EP | disclosed |
| EP-0190534-A1 | Process for the preparation of ergoline derivatives | SCHERING AKTIENGESELLSCHAFT (DE) | 1986-08-13 | — | — | EP | disclosed |
| EP-0160842-A2 | 2-Substituted ergoline derivatives, processes for their preparation, and their use as medicaments | SCHERING AKTIENGESELLSCHAFT (DE) | 1985-11-13 | — | — | EP | disclosed |