Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | FABP7 | O15540 | 1/20 | 0.44 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | BACE1 | P56817 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2679496 | 1.00 | TSHR (0.48) | TSHRGLAFABP7FABP5ALDH1A1 | |
| SCHEMBL6165123 | 1.00 | TSHR (0.48) | TSHRGLAFABP7FABP5ALDH1A1 | |
| SCHEMBL19234323 | 1.00 | TSHR (0.48) | TSHRGLAFABP7FABP5ALDH1A1 | |
| Hydrochloric Acid SCHEMBL1784261 | 0.99 | TSHR (0.50) | TSHRGLAFABP7FABP5ALDH1A1 | |
| SCHEMBL7265457 | 0.85 | CA1 (0.48) | TSHRALDH1A1KMT2AFKBP1A | |
| SCHEMBL19233846 | 0.84 | GLA (0.47) | TSHRGLAFABP7FABP5ALDH1A1 | |
| SCHEMBL7436597 | 0.84 | TSHR (0.47) | TSHRGLAFABP7FABP5ALDH1A1 | |
| SCHEMBL29109592 | 0.84 | TSHR (0.53) | TSHRGLAFABP7FABP5ALDH1A1 | |
| SCHEMBL19233842 | 0.84 | TSHR (0.47) | TSHRGLAFABP7FABP5ALDH1A1 | |
| SCHEMBL11464612 | 0.82 | ALDH1A1 (0.50) | TSHRGLAFABP7FABP5ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5674905-A | ADMINISTERING AS GASTRIN OR CHOLECYSTOKININ ANTAGONISTS | JAMES BLACK FOUNDATION LIMITED (GB) | 1997-10-07 | — | — | US | disclosed |
| EP-0655053-B1 | BICYCLOOCTANE AND BICYCLOHEPTANE DERIVATIVES | BLACK JAMES FOUNDATION (GB) | 1997-09-03 | — | — | EP | disclosed |
| EP-0655053-A1 | BICYCLOOCTANE AND BICYCLOHEPTANE DERIVATIVES. | BLACK JAMES FOUNDATION (GB) | 1995-05-31 | — | — | EP | disclosed |
| WO-1994000421-A1 | BICYCLOOCTANE AND BICYCLOHEPTANE DERIVATIVES | JAMES BLACK FOUNDATION LIMITED (GB) | 1994-01-06 | — | — | WO | disclosed |